2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Carbonic Anhydrase Apoptosis CDK
  4. Carbonic anhydrase inhibitor 33

Carbonic anhydrase inhibitor 33 (11D) 是一种同时抑制 CA (碳酸酐酶) IX/XII 和 CDK6 的双重抑制剂，其对 hCA IX 和 hCA XII 的 Ki 值分别为 19.7 nM 和 26.1 nM。Carbonic anhydrase inhibitor 33 (11D) 可诱导 G1 期细胞周期阻滞和细胞凋亡。Carbonic anhydrase inhibitor 33 (11D) 可用于非小细胞肺癌 (NSCLC) 相关的研究。

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Carbonic anhydrase inhibitor 33

Carbonic anhydrase inhibitor 33 Chemical Structure

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Carbonic anhydrase inhibitor 33 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA IX CA XII

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carbonic anhydrase inhibitor 33 (11D) is a dual inhibitor of CA (Carbonic anhydrase) IX/XII and CDK6, with Ki values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC[1].

IC50 & Target[1]

hCA IX

19.7 nM (Ki)

hCA XII

26.1 nM (Ki)

hCA II

76.1 nM (Ki)

hCA I

663 nM (Ki)

CDK6

0.069 μM (IC50)

体外研究
(In Vitro)

Carbonic anhydrase inhibitor 33 (11D) 在 A549 和 NCI-H1734 细胞中的 IC50 值分别为 2.39 μM 和 7.92 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carbonic anhydrase inhibitor 33 相关抗体:
分子量

410.42

Formula

C19H15FN6O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carbonic anhydrase inhibitor 33 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbonic anhydrase inhibitor 33Carbonic anhydrase inhibitor33Carbonic anhydrase inhibitor-33Carbonic AnhydraseApoptosisCDKCarbonate dehydrataseCyclin dependent kinaseNSCLChCA IXhCA XIIInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-172899
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