2. Immunology/Inflammation Cytoskeleton TGF-beta/Smad Cell Cycle/DNA Damage Stem Cell/Wnt
  3. IFNAR ROCK
  4. Centaureidin

Centaureidin 是一种口服有效的干扰素 (IFN) 诱导剂，可从鬼针草 (Bidens pilosa) 中分离得到，其 EC50 为 0.9 μg/mL。Centaureidin 通过激活 Rho 信号通路，导致肌动蛋白和微管蛋白解聚，进而引发黑色素细胞的树突退缩和应力纤维形成。Centaureidin 对肿瘤细胞生长具有显著抑制作用。Centaureidin 能明显缓解小鼠足爪水肿[1][2][3][4][5]。

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Centaureidin Chemical Structure

Centaureidin Chemical Structure

CAS No. : 17313-52-9

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Centaureidin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC50 of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice[1][2][3][4][5].

体外研究
(In Vitro)

Centaureidin (2 μg/mL, 24-72 h) 可刺激 T 细胞系和 Jurkat 细胞中 IFN-γ 的转录[1]。

Centaureidin (0.5 μM, 6 days) 能抑制 NHEM 细胞中黑素小体的转移并诱导细胞形态学改变[2]。

Centaureidin (0.5 μM, 24-72 h) 可减少 NHEM 细胞的树突形成和应力纤维形成[2]。

Centaureidin (0.5 μM, 30-240 min) 能激活 NHEM 细胞中 Rho 信号通路，但对 Rac 或 CDC42 无影响[2]。

Centaureidin (72 h) 显示出较强的细胞生长抑制活性，对 HeLa 细胞、MCF-7 细胞和 A-431 细胞的 IC50 值分别为 0.0819 μM、0.1250 μM 和 0.3540 μM[3]。

Centaureidin (10-100 μM) 能以浓度依赖的方式完全松弛由 Norepinephrine (NA) (HY-13715) (IC50 = 16.7 μM) 或高钾浓度 (IC50 = 16.1 μM) 诱导的完整大鼠主动脉环收缩[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Centaureidin 相关抗体:

Western Blot Analysis[2]

Cell Line: NHEM cells
Concentration: 0.5 μM
Incubation Time: 30, 60, 240 min
Result: Increased GTP-bound Rho content nearly 200% at 30 min, whereas GTP-Rac content showed only a slight increase.
Elevated GTP-Rho at 4 h.
Decreased the level of GTP CDC42.
体内研究
(In Vivo)

Centaureidin (25 mg/kg, 口服给药) 显著抑制了由 Carrageenan (HY-125474)  诱导的小鼠足部水肿[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss mice (15-25 g) injected with 0.05 mL 3% Carrageenan (Type IV) in saline[5]
Dosage: 25 mg/kg
Administration:
Result: Inhibited paw edema by 55.5% at 5 h post-carrageenan injection.
分子量

360.31

Formula

C18H16O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Centaureidin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Centaureidin17313-52-9IFNARROCKInterferon-α/β receptorInterferon-alpha/beta receptor Rho-associated protein kinaseRho-associated kinaseRho-kinaseROKRhomelanosomeactintubulinHeLaMCF-7IFNγNHEMInhibitorinhibitorinhibit

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