1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. CGP 78608 hydrochloride

CGP 78608 hydrochloride 

目录号: HY-107701 纯度: 99.56%
COA 产品使用指南

CGP 78608 hydrochlorid 是 NMDA 受体甘氨酸结合位点的一种高效选择性拮抗剂,IC50 为 6 nM。CGP 78608 hydrochloride 作为 GluN1/GluN3A 介导的甘氨酸电流的增强剂,EC50 值为 26.3 nM。具有抗惊厥活性。

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CGP 78608 hydrochloride Chemical Structure

CGP 78608 hydrochloride Chemical Structure

CAS No. : 1135278-54-4

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规格 价格 是否有货 数量
1 mg ¥1059
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of CGP 78608 hydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 hydrochloride acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2].

IC50 & Target

NMDA Receptor

 

体外研究
(In Vitro)

CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2].
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

414.58

Formula

C11H14BrClN3O5P

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

1 M NaOH 中的溶解度 : ≥ 50 mg/mL (120.60 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4121 mL 12.0604 mL 24.1208 mL
5 mM 0.4824 mL 2.4121 mL 4.8242 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

CGP 78608 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
1 M NaOH 1 mM 2.4121 mL 12.0604 mL 24.1208 mL 60.3020 mL
5 mM 0.4824 mL 2.4121 mL 4.8242 mL 12.0604 mL
10 mM 0.2412 mL 1.2060 mL 2.4121 mL 6.0302 mL
15 mM 0.1608 mL 0.8040 mL 1.6081 mL 4.0201 mL
20 mM 0.1206 mL 0.6030 mL 1.2060 mL 3.0151 mL
25 mM 0.0965 mL 0.4824 mL 0.9648 mL 2.4121 mL
30 mM 0.0804 mL 0.4020 mL 0.8040 mL 2.0101 mL
40 mM 0.0603 mL 0.3015 mL 0.6030 mL 1.5075 mL
50 mM 0.0482 mL 0.2412 mL 0.4824 mL 1.2060 mL
60 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0050 mL
80 mM 0.0302 mL 0.1508 mL 0.3015 mL 0.7538 mL
100 mM 0.0241 mL 0.1206 mL 0.2412 mL 0.6030 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CGP 78608 hydrochloride
目录号:
HY-107701
需求量: