1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CGP 78608 hydrochloride

CGP 78608 hydrochloride 

目录号: HY-107701
产品使用指南

CGP 78608 hydrochlorid 是 NMDA 受体甘氨酸结合位点的一种高效选择性拮抗剂,IC50 为 6 nM。CGP 78608 作为 GluN1/GluN3A 介导的甘氨酸电流的增强剂,EC50 值为 26.3 nM。具有抗惊厥活性。

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CGP 78608 hydrochloride Chemical Structure

CGP 78608 hydrochloride Chemical Structure

CAS No. : 1135278-54-4

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生物活性

CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2].

体外研究
(In Vitro)

CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2].
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

414.58

Formula

C11H14BrClN3O5P

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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  • 稀释计算器

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产品名称:
CGP 78608 hydrochloride
目录号:
HY-107701
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