2. Cell Cycle/DNA Damage
  3. CDK
  4. Cimpuciclib

Cimpuciclib 是一种选择性的 CDK4 抑制剂 (IC50: 0.49 nM)，具有抗肿瘤活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Cimpuciclib tosylate 通常具有更好的水溶性和稳定性。

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Cimpuciclib Chemical Structure

Cimpuciclib Chemical Structure

CAS No. : 2202767-78-8

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规格 是否有货
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100 mg   询价  
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Cimpuciclib 的其他形式现货产品:

Customer Review

Other Forms of Cimpuciclib:

Cimpuciclib 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cimpuciclib is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1].

IC50 & Target[1]

CDK4

0.49 nM (IC50)

CDK6

9.56 nM (IC50)

体外研究
(In Vitro)

Cimpuciclib (example 63, 141.2 nM, 6 days) inhibits proliferation in colo205 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cimpuciclib 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Colo205 cells
Concentration: 0-500 nM approximately
Incubation Time: 6 days
Result: Inhibited cell proliferation with an IC50 value of 141.2 nM.
体内研究
(In Vivo)

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) shows slow metabolic rate and maintains high concentration in the plasma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colo205 tumor-bearing mice[1]
Dosage: 50 mg/kg, twice a week
Administration: Oral gavage
Result: Inhibited tumor growth by 93.63%.
Animal Model: Rats, colo205 tumor-bearing mice[1]
Dosage: 5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration: Oral administration
Result: Pharmacokinetic profile of Cimpuciclib (example 63).
dose (mg/kg) Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mL•h) t1/2 (h)
5 mg/kg (rats) 559.7 6 5414 2.4
50 mg/kg (mice) 7960 1 136782 14.8
分子量

542.65

Formula

C30H35FN8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cimpuciclib 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cimpuciclib2202767-78-8CDKCyclin dependent kinaseCancertumorcolo205proliferationInhibitorinhibitorinhibit

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目录号：
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