1. Cell Cycle/DNA Damage
  2. CDK
  3. Cimpuciclib tosylate

Cimpuciclib tosylate 

目录号: HY-112243A 纯度: 99.16%
COA 产品使用指南

Cimpuciclib tosylate 是一种选择性的 CDK4 抑制剂 (IC50: 0.49 nM),具有抗肿瘤活性。

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Cimpuciclib tosylate Chemical Structure

Cimpuciclib tosylate Chemical Structure

CAS No. : 2408872-84-2

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规格 价格 是否有货 数量
1 mg ¥3120
In-stock
5 mg ¥7800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of Cimpuciclib tosylate:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1].

IC50 & Target[1]

CDK4

0.49 nM (IC50)

CDK6

9.56 nM (IC50)

体外研究
(In Vitro)

Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Colo205 cells
Concentration: 0-500 nM approximately
Incubation Time: 6 days
Result: Inhibited cell proliferation with an IC50 value of 141.2 nM.
体内研究
(In Vivo)

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colo205 tumor-bearing mice[1]
Dosage: 50 mg/kg, twice a week
Administration: Oral gavage
Result: Inhibited tumor growth by 93.63%
Animal Model: Rats, colo205 tumor-bearing mice[1]
Dosage: 5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration: Oral administration
Result: Pharmacokinetic profile of Cimpuciclib (example 63).
dose Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mL•h) t1/2 (h)
5 mg/kg (rats) 559.7 6 5414 2.4
50 mg/kg (mice) 7960 1 136782 14.8
分子量

714.85

Formula

C37H43FN8O4S

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 200 mg/mL (279.78 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3989 mL 6.9945 mL 13.9889 mL
5 mM 0.2798 mL 1.3989 mL 2.7978 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Cimpuciclib tosylate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3989 mL 6.9945 mL 13.9889 mL 34.9724 mL
5 mM 0.2798 mL 1.3989 mL 2.7978 mL 6.9945 mL
10 mM 0.1399 mL 0.6994 mL 1.3989 mL 3.4972 mL
15 mM 0.0933 mL 0.4663 mL 0.9326 mL 2.3315 mL
20 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7486 mL
25 mM 0.0560 mL 0.2798 mL 0.5596 mL 1.3989 mL
30 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
40 mM 0.0350 mL 0.1749 mL 0.3497 mL 0.8743 mL
50 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6994 mL
60 mM 0.0233 mL 0.1166 mL 0.2331 mL 0.5829 mL
80 mM 0.0175 mL 0.0874 mL 0.1749 mL 0.4372 mL
100 mM 0.0140 mL 0.0699 mL 0.1399 mL 0.3497 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cimpuciclib tosylate
目录号:
HY-112243A
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