2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR TNF Receptor
  4. Cinrebafusp alfa

Cinrebafusp alfa  (Synonyms: PRS 343)

目录号: HY-P99605 纯度: 98.53%
COA

摩尔计算器

Cinrebafusp alfa (PRS 343) 是一种高亲和力的 CD137/HER2 双特异性抗钙蛋白药物。Cinrebafusp alfa 结合重组人 HER2 (Kd=0.3 nM) 和人单体 CD137 (4-1BB; Kd=5 nM)。Cinrebafusp alfa 通过肿瘤定位的 HER2 依赖性 4-1BB 聚集和激活促进 T 细胞共刺激，进一步增强 T 细胞受体介导的活性并导致肿瘤破坏。Cinrebafusp alfa 具有用于 HER2+ 实体瘤研究的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cinrebafusp alfa Chemical Structure

Cinrebafusp alfa Chemical Structure

CAS No. : 2218515-90-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥4000
In-stock
5 mg ￥10400
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Cinrebafusp alfa 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research[1][2].

IC50 & Target[1]

4-1BB

5 nM (Kd)

HER2

0.3 nM (Kd)

体外研究
(In Vitro)

Cinrebafusp alfa (PRS 343) 结合表达 HER2 的 MCF-7 细胞和转染人 4-1BB 的 CHO 细胞，在 FACS 测定中 EC50 分别为 7.4 nmol/L，6.2 nmol/L[1 ]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cinrebafusp alfa 相关抗体:
体内研究
(In Vivo)

Cinrebafusp alfa (PRS 343; 0.2-10 mg/kg; 静脉给药; 每周一次; 持续 20 天) 在移植有 HER2 阳性 SK-OV-3 肿瘤细胞的人源化小鼠模型中导致肿瘤生长抑制并且肿瘤浸润淋巴细胞呈剂量依赖性增加[1]。
Cinrebafusp alfa (10 mg/kg; 静脉给药; 单剂量) 在雄性 CD-1 小鼠中的终末消除半衰期为 >14 天。Cinrebafusp alfa (3 mg/kg; 静脉注射; 单剂量) 在雄性食蟹猴中的终末消除半衰期约为 4 天[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SK-OV-3 ovarian cancer model in human PBMC-reconstituted NOG female mice, ages 5-7 weeks[1]
Dosage: 0.2, 1, 5, 10 mg/kg
Administration: IV; once weekly; for 20 day
Result: Displayed dose-dependent antitumor efficacy with doses ranging from 4 μg to 100 μg (approximately 0.2 mg/kg to 5 mg/kg), while the 200-μg dose (approximately 10 mg/kg) did not further enhance tumor regression.
Led to a significant increase in human CD45+ lymphocytes in tumor tissue.
Animal Model: Male CD-1 mice[1]
Dosage: 10 mg/kg (Pharmacokinetic Analysis)
Administration: IV; single dose
Result: Had the terminal elimination half-life of >14 days.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cinrebafusp alfa 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinrebafusp alfa2218515-90-1PRS 343PRS343PRS-343EGFRTNF ReceptorEpidermal growth factor receptorErbB-1HER1Tumor Necrosis Factor ReceptorTNFRCD137HEr2anticalinT-cellcostimulation4-1BBsolid tumorsMCF-7CHO cellSK-OV-3ovarian cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Cinrebafusp alfa
目录号：
HY-P99605
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z