2. Metabolic Enzyme/Protease Apoptosis Anti-infection NF-κB
  3. Heme Oxygenase (HO) Apoptosis Bcl-2 Family Caspase Cytochrome P450 Bacterial Keap1-Nrf2
  4. Co(III) protoporphyrin IX chloride

Co(III) protoporphyrin IX chloride  (Synonyms: 原卟啉氯化钴; Protoporphyrin IX cobaltic chloride; CoPPIX-Cl)

目录号: HY-W250116 纯度: ≥95.0%
COA 产品使用指南 技术支持

Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) 是一种 HO-1 诱导剂。Co(III) protoporphyrin IX chloride 具有抗炎、抗菌等活性。Co(III) protoporphyrin IX chloride 也可用于缺血再灌注损伤模型的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Co(III) protoporphyrin IX chloride Chemical Structure

Co(III) protoporphyrin IX chloride Chemical Structure

CAS No. : 102601-60-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥960
In-stock
10 mg ￥1560
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Co(III) protoporphyrin IX chloride 相关抗体

Top Publications Citing Use of Products

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看所有亚型
HO-1 HO-2

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co(III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co(III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models[1][2][3][4].

IC50 & Target[3]

Caspase 3

 

Bcl-2

 

HO-1

 

体外研究
(In Vitro)

Co(III) protoporphyrin IX chloride (0-25 μM; 2-16 小时) 在 Huh-7 细胞中可上调 HO-1、Nrf2 水平，并减低 Bach1 的蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Co(III) protoporphyrin IX chloride 相关抗体:

Western Blot Analysis[1]

Cell Line: Huh-7 cells
Concentration: 0, 0.5, 1, 5 and 10 μM
Incubation Time: 16 h
Result: Increased the levels of HO-1 and Nrf2 in a dose-dependent manner.
Inhibited the levels of Bach1 in a dose-dependent manner.
体内研究
(In Vivo)

Co(III) protoporphyrin IX chloride (125 μmol/kg; 皮下注射; 单剂量) 在雄性大鼠中可降低肝脏中细胞色素 P450 水平，同时抑制 δ-氨基乙酰丙酸合酶活性并诱导血红素加氧酶活性[2]。
Co(III) protoporphyrin IX chloride (5 mg/kg; 腹腔注射; 单剂量) 在小鼠肝脏缺血再灌注损伤模型中具有改善作用[3]。
Co(III) protoporphyrin IX chloride (5 mg/kg; 腹腔注射; 6 次, 11 天) 在感染鼠疫耶尔森菌的小鼠中具有抗菌活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (25-30 g) with liver ischemia-reperfusion (I/R) injury[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; single dose
Result: Significantly reduced the increase in serum levels of AST and ALT induced by I/R injury.
Alleviated hepatocellular swelling and histopathological damage.
Increased the protein expression levels of HO-1 and Bcl-2, decreased the expression of caspase 3, and reduced the percentage of apoptotic hepatocytes compared with the I/R group.
Animal Model: C57BL/6 mice treated Yersinia pestis CO92[4]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 24 h prior to challenge and on the day of challenge, additional treatments were provided every other day for the duration of the 10-day observation period
Result: Improved survival, increased the time to mortality, reduced pulmonary bacterial burden, and increased HO-1 levels in the lungs compared to vehicle-treated mice.
分子量

655.03

Formula

C34H32ClCoN4O4
CAS 号
性状

固体

颜色

Brown to black

中文名称

原卟啉氯化钴
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 62.5 mg/mL (95.42 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5266 mL 7.6332 mL 15.2665 mL
5 mM 0.3053 mL 1.5266 mL 3.0533 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥95.0%

COA (301 KB) HNMR (285 KB) MS (71 KB)

产品使用指南 (1538 KB)
参考文献

Co(III) protoporphyrin IX chloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5266 mL 7.6332 mL 15.2665 mL 38.1662 mL
5 mM 0.3053 mL 1.5266 mL 3.0533 mL 7.6332 mL
10 mM 0.1527 mL 0.7633 mL 1.5266 mL 3.8166 mL
15 mM 0.1018 mL 0.5089 mL 1.0178 mL 2.5444 mL
20 mM 0.0763 mL 0.3817 mL 0.7633 mL 1.9083 mL
25 mM 0.0611 mL 0.3053 mL 0.6107 mL 1.5266 mL
30 mM 0.0509 mL 0.2544 mL 0.5089 mL 1.2722 mL
40 mM 0.0382 mL 0.1908 mL 0.3817 mL 0.9542 mL
50 mM 0.0305 mL 0.1527 mL 0.3053 mL 0.7633 mL
60 mM 0.0254 mL 0.1272 mL 0.2544 mL 0.6361 mL
80 mM 0.0191 mL 0.0954 mL 0.1908 mL 0.4771 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Co(III) protoporphyrin IX102601-60-5Protoporphyrin IX cobaltic CoPPIX-Cl原卟啉氯化钴Heme Oxygenase (HO)ApoptosisBcl-2 FamilyCaspaseCytochrome P450BacterialKeap1-Nrf2Heme OxygenaseCYPsHuh-7 cellsischemia-reperfusion injury modelYersinia pestisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Co(III) protoporphyrin IX chloride
目录号：
HY-W250116
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z