2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Conantokin-T

Conantokin-T 是一种含有 γ-羧基谷氨酸的 N-甲基-D-天冬氨酸 (NMDA) 拮抗肽，IC50 值为2 μM。Conantokin-T 在中枢神经系统神经元中抑制 NMDA 受体介导的钙内流。Conantokin-T 可以从捕鱼锥蜗牛 Conus tulipa 的毒液中纯化。

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Custom Peptide Synthesis

Conantokin-T Chemical Structure

Conantokin-T Chemical Structure

CAS No. : 127476-26-0

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Conantokin-T 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa[1].

IC50 & Target

IC50: 2 μM (NMDA)[1]
体外研究
(In Vitro)

Conantokin-T produces a partial antagonism of NMDA receptor function with an IC50 value of 2 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Conantokin-T 相关抗体:
体内研究
(In Vivo)

Conantokin-T induces sleep-like symptoms in young mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2683.81

Formula

C110H175N31O45S
CAS 号
Sequence Shortening

GE-{Gla}-{Gla}-YQKML-{Gla}-NLR-{Gla}-AEVKKNA-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Conantokin-T 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conantokin-T127476-26-0iGluRIonotropic glutamate receptorsγ-carboxyglutamateN-methyl-D-aspartate (NMDA)amino acidcalcium influxcentral nervous systemneuronsConus tulipaInhibitorinhibitorinhibit

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