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Corifollitropin alfa  (Synonyms: Org 36286; MK-8962)

目录号: HY-118860

Corifollitropin alfa (Org 36286) 是一种长效的重组促卵泡激素 (FSH) 类似物。Corifollitropin alfa 是一种 FSH Receptor 激动剂,EC50 为 5.0 pM。Corifollitropin alfa 可刺激排卵,可用于不孕症研究。

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Corifollitropin alfa Chemical Structure

Corifollitropin alfa Chemical Structure

CAS No. : 195962-23-3

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Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility[1][2][3].

IC50 & Target

FSH Receptor[2]

(In Vivo)

Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t1/2 of 17.3 h and Cmax of 3.2 ng/mL/μg/kg in female Wistar rats[2].
Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats[2].
Corifollitropin alfa (3 µg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: 2.5, 5, 10, 20, 40 μg/kg.
Administration: Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h).
Result: Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.

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Corifollitropin alfa