1. Metabolic Enzyme/Protease
  2. MMP
  3. CTTHWGFTLC, CYCLIC

CTTHWGFTLC, CYCLIC 

目录号: HY-P1789
产品使用指南

CTTHWGFTLC, CYCLIC 是基质金属蛋白酶 MMP-2MMP-9 的环肽抑制剂。

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Custom Peptide Synthesis

CTTHWGFTLC, CYCLIC Chemical Structure

CTTHWGFTLC, CYCLIC Chemical Structure

CAS No. : 244082-19-7

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Description

CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9[1].

IC50 & Target[1]

MMP-2

 

MMP-9

 

Molecular Weight

1166.33

Formula

C₅₂H₇₁N₁₃O₁₄S₂

CAS No.

244082-19-7

Sequence

{Cys}{Thr}{Thr}{His}{Trp}{Gly}{Phe}{Thr}{Leu}{Cys} (Disulfide Bridge: Cys1-Cys10)

Sequence Shortening

CTTHWGFTLC (Disulfide Bridge: Cys1-Cys10)

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
CTTHWGFTLC, CYCLIC
目录号:
HY-P1789
需求量:

CTTHWGFTLC, CYCLIC

Cat. No.: HY-P1789