Cyanidin 3-sambubioside chloride  (Synonyms: Cyanidin-3-O-sambubioside chloride)

Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC₅₀ of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties^[1][2][3].

Cyanidin 3-sambubioside chloride (5-25 μg/mL, 24 h) 具有清除 DPPH 自由基、抗氧化活性和还原能力^[1]。
Cyanidin 3-sambubioside chloride (50-400 μM, 24 h) 可在 LPS (HY-D1056) 诱导的 RAW 264.7 细胞中抑制 NO 的产生^[1]。
Cyanidin 3-sambubioside chloride (1-30 µg/mL, 24 h) 可在鸡胚绒毛尿囊膜 (CAM) 中抑制血管生成，在 HUVEC 细胞抑制管状结构形成，并通过抑制 Akt 磷酸化和 MMP-9 来抑制 MDA-MB-231 细胞的迁移和侵袭^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

616.95

C₂₆H₂₉ClO₁₅

33012-73-6

固体

Brown to black

氯化花青素-3-桑布双糖苷

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Jung-Chu Cheng, et al. Detection of cyanidin in different-colored peanut testae and identification of peanut cyanidin 3-sambubioside. J Agric Food Chem. 2009 Oct 14;57(19):8805-11.  [Content Brief]

  [2]. S Kannan, et al. The inhibitory performance of flavonoid cyanidin-3-sambubiocide against H274Y mutation in H1N1 influenza virus. J Biomol Struct Dyn. 2018 Dec;36(16):4255-4269.  [Content Brief]

  [3]. Sang-Jin Lee, et al. Cyanidin-3-O-sambubioside from Acanthopanax sessiliflorus fruit inhibits metastasis by downregulating MMP-9 in breast cancer cells MDA-MB-231. Planta Med. 2013 Nov;79(17):1636-40.  [Content Brief]