2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. D15

D15  (Synonyms: Dynamin II (828–842))

目录号: HY-P1386
产品使用指南 技术支持

D15 是一种含有动力蛋白 15 个氨基酸片段的多肽，是一种 AMPAR 内吞抑制剂。D15 可阻断动力蛋白与两性蛋白 1 和 2 的相互作用。D15 显著提高 Sapap3 KO 小鼠的中等多棘神经元 (MSNs) 中 AMPAR 兴奋性突触后电位 (EPSC) 幅度。D15 可用于神经精神疾病研究。

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Custom Peptide Synthesis

D15

D15 Chemical Structure

CAS No. : 251939-41-0

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D15 相关抗体

Top Publications Citing Use of Products

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research[1].

IC50 & Target[1]

AMPA Receptor

 

分子量

1566.76

Formula

C69H111N23O19
CAS 号
Sequence

Pro-Pro-Pro-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-Pro-Gly
Sequence Shortening

PPPQVPSRPNRAPPG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D15251939-41-0Dynamin II (828–842)D 15D-15iGluRIonotropic glutamate receptorsPeptideAMPAREndocytosisInhibitorMedium spiny neuronsMSNEPSCNeuropsychiatric disorderinhibitorinhibit

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