1. Others JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  2. Isotope-Labeled Compounds EGFR Apoptosis
  3. Dacomitinib-d10 dihydrochloride

Dacomitinib-d10 dihydrochloride  (Synonyms: PF-00299804-d10 dihydrochloride; PF-299804-d10 dihydrochloride)

目录号: HY-13272S2
COA 产品使用指南

Dacomitinib-d10 (dihydrochloride) 是 Dacomitinib dihydrochloride 的氘代物。Dacomitinib (PF-00299804) dihydrochloride 是一种特异,不可逆的 ERBB 家族抑制剂,作用于 EGFRERBB2ERBB4IC50 分别为 6 nM,45.7 nM 和 73.7 nM

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Dacomitinib-d<sub>10</sub> dihydrochloride Chemical Structure

Dacomitinib-d10 dihydrochloride Chemical Structure

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规格 是否有货
1 mg
询价
5 mg
询价

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Customer Review

Other Forms of Dacomitinib-d10 dihydrochloride:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dacomitinib-d10 (dihydrochloride) is the deuterium labeled Dacomitinib dihydrochloride. Dacomitinib (PF-00299804) dihydrochloride is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

552.92

Formula

C24H17D10Cl3FN5O2

性状

固体

颜色

White to off-white

中文名称

达克替尼 d10 (双盐酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥95.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Dacomitinib-d10 dihydrochloride
目录号:
HY-13272S2
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