2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite G protein-coupled Bile Acid Receptor 1
  4. Deoxycholic acid sodium hydrate

Deoxycholic acid sodium hydrate  (Synonyms: 去氧胆酸钠盐; Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate)

目录号: HY-N0593B
产品使用指南

摩尔计算器

Deoxycholic acid (cholanoic acid) sodium hydrate 是一种胆汁酸，肠道代谢副产物，可以激活 G 蛋白偶联胆汁酸受体 TGR5。

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Deoxycholic acid sodium hydrate Chemical Structure

Deoxycholic acid sodium hydrate Chemical Structure

CAS No. : 145224-92-6

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Deoxycholic acid sodium hydrate 的其他形式现货产品:

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Deoxycholic acid sodium hydrate 相关抗体

Top Publications Citing Use of Products

    Deoxycholic acid sodium hydrate purchased from MCE. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24.  [Abstract]

    Western blotting results indicated that the inhibition of SOX2 in bile acid-treated AGS cells is partially rescued in miR-21 knockdown AGS cells.

    Deoxycholic acid sodium hydrate purchased from MCE. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24.  [Abstract]

    The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.

    Deoxycholic acid sodium hydrate purchased from MCE. Usage Cited in: Cancer Cell Int. 2019 Jan 31;19:24.  [Abstract]

    The expression of CDX2, KLF4, HNF4α, and cadherin 17 is increased upon stimulation with DCA in a dose-dependent manner.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Deoxycholic acid (cholanoic acid) sodium hydrate，a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].

    IC50 & Target

    Microbial Metabolite

     

    体外研究
    (In Vitro)

    Deoxycholic acid sodium hydrate (DCA) (100 μM) induces the production of gastric cancer cell line MGC803 resistant to acidified bile acids and enhances their survival and proliferation activity under bile acid stress[2].
    Deoxycholic acid sodium hydrate (DCA) (100 μM)-induced resistant cells shows altered morphology, significantly elevated telomerase activity, better cell viability and reduces apoptosis compared to normal MGC803 cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Deoxycholic acid sodium hydrate 相关抗体:
    Clinical Trial
    分子量

    432.57

    Formula

    C24H41NaO5
    CAS 号
    中文名称

    去氧胆酸钠盐
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Deoxycholic acid sodium hydrate 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Deoxycholic acid sodium145224-92-6Cholanoic Acid sodiumDesoxycholic acid sodium去氧胆酸钠盐Endogenous MetaboliteG protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1bile acidG protein-coupled bile acid receptorInhibitorinhibitorinhibit

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