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  3. Diloxanide

Diloxanide (Synonyms: 二氯尼特)

目录号: HY-119972
产品使用指南

Diloxanide 是一种抗原虫制剂 (anti-protozoal agent),可用于组织学内阿米巴原虫或者其他原虫感染引起的无症状肠道阿米巴病的研究。Diloxanide 是一种活性的鲁米那抗阿米巴试剂,在胃肠道中,由其前药二氯尼特糠酸酯 (HY-B1147) 水解得来。

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Diloxanide Chemical Structure

Diloxanide Chemical Structure

CAS No. : 579-38-4

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Description

Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1].

In Vivo

Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1].
Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].

Molecular Weight

234.08

Formula

C₉H₉Cl₂NO₂

CAS No.

579-38-4

中文名称

安特酰胺;二氯散;二氯尼特;安特山胺

SMILES

O=C(C(Cl)Cl)N(C)C1=CC=C(C=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DiloxanideParasiteanti-protozoalEntamoeba histolyticainfectionluminal amebicideamoebic colitisInhibitorinhibitorinhibit

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