2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor 5-HT Receptor
  4. Dimethothiazine

Dimethothiazine  (Synonyms: Dimetotiazine; Fonazine)

目录号: HY-A0157
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Dimethothiazine (Dimetotiazine; Fonazine) 是一种具有口服活性三环抗组胺 (histamine)、抗 5-HT 剂，对去大脑抗僵直活性高，有少量镇静作用和少量催眠作用。在去脑猫模型中，Dimethothiazine 可减少或消除静态和动态融合运动对肌肉纺锤体的影响。Dimethothiazine 可用于偏头痛和痉挛的研究。

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Dimethothiazine Chemical Structure

Dimethothiazine Chemical Structure

CAS No. : 7456-24-8

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Dimethothiazine 相关抗体

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生物活性

Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity[1][2][3].

IC50 & Target

Histamine, 5-HT[1]
体内研究
(In Vivo)

Dimethothiazine (0.5-16 mg/kg; i.v.; single dosage) reduces decerebrate rigidity in cats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)[2]
Dosage: 0.5, 1, 2, 4, 8 and 16 mg/kg
Administration: i.v.; single dosage
Result: Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg.
Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots.
Reduced the activity of the dynamic fusimotor fibres.
分子量

391.55

Formula

C19H25N3O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dimethothiazine 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethothiazine7456-24-8Dimetotiazine FonazineHistamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptordecerebratehemicraniaspasticityInhibitorinhibitorinhibit

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