2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Dovitinib dilactic acid

Dovitinib dilactic acid  (Synonyms: 多韦替尼; CHIR-258 dilactic acid; TKI258 dilactic acid)

目录号: HY-13892
产品使用指南

摩尔计算器

Dovitinib (dilactic acid) 是一种具有口服活性的 VEGF kinase 抑制剂。Dovitinib (dilactic acid) 抑制实体癌和血液癌中相关的受体酪氨酸激酶 (RTKs) 以及和肿瘤血管生成。

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Dovitinib dilactic acid Chemical Structure

Dovitinib dilactic acid Chemical Structure

CAS No. : 852433-84-2

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Dovitinib dilactic acid 的其他形式现货产品:

Customer Review

Other Forms of Dovitinib dilactic acid:

Dovitinib dilactic acid 相关抗体

Top Publications Citing Use of Products

    Dovitinib dilactic acid purchased from MCE. Usage Cited in: Front Cell Dev Biol. 2020 May 7;8:287.  [Abstract]

    Determination in L3.6 cells of FGF2-induced FGFR phosphorylation by Western blot in the presence of Dovitinib. FGFR1 and alpha-Tubulin are used as loading controls.

    Dovitinib dilactic acid purchased from MCE. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.  [Abstract]

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

    查看 VEGFR 亚型特异性产品:

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    VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Dovitinib (dilactic acid) is an orally active inhibitor of VEGF kinase. Dovitinib (dilactic acid) inhibits receptor tyrosine kinases (RTKs) involved in solid and hematologic cancers and tumor angiogenesis[1].

    分子量

    572.59

    Formula

    C27H33FN6O7
    CAS 号
    中文名称

    多韦替尼
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : ≥ 30 mg/mL (52.39 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.7465 mL 8.7323 mL 17.4645 mL
    5 mM 0.3493 mL 1.7465 mL 3.4929 mL
    查看完整储备液配制表

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献

    Dovitinib dilactic acid 相关分类

    完整储备液配制表

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7465 mL 8.7323 mL 17.4645 mL 43.6613 mL
    5 mM 0.3493 mL 1.7465 mL 3.4929 mL 8.7323 mL
    10 mM 0.1746 mL 0.8732 mL 1.7465 mL 4.3661 mL
    15 mM 0.1164 mL 0.5822 mL 1.1643 mL 2.9108 mL
    20 mM 0.0873 mL 0.4366 mL 0.8732 mL 2.1831 mL
    25 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.7465 mL
    30 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4554 mL
    40 mM 0.0437 mL 0.2183 mL 0.4366 mL 1.0915 mL
    50 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.8732 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dovitinib852433-84-2CHIR-258TKI258多韦替尼CHIR258CHIR 258TKI 258TKI-258VEGFRVascular endothelial growth factor receptorVascular endothelial growth factorVEGFSolid cancerHmatologic cancerInhibitorinhibitorinhibit

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