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  4. DS01080522

DS01080522 是 PRKACA 的抑制剂。DS01080522 抑制 PRKACA 激酶的活性以及 CREB 磷酸化，其 IC50 值分别为 0.8 和 66 nM。DS0108052 可用于癌症的研究。

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DS01080522 Chemical Structure

DS01080522 Chemical Structure

CAS No. : 2832159-84-7

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DS01080522 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.8 nM (PRKACA kinase), 66 nM (CREB phosphorylation)[1]
体外研究
(In Vitro)

DS01080522 (1-10 μM; 30 min) affects phosphorylation of CREB[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DS01080522 相关抗体:

Cell Viability Assay[1]

Cell Line: NIH/3T3 cells
Concentration: 1-10 μM
Incubation Time: 30 min
Result: Dose-dependently decreased the phosphorylation level of CREB which is a marker of intracellular PRAKACA inhibitory activity in NIH/3T3 cells with an IC50 value of 66 nM.
分子量

471.34

Formula

C23H20Cl2N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DS01080522 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS010805222832159-84-7DS 01080522DS-01080522Othersphosphorylationfibrolamellarhepatocellular carcinomaNIH/3T3cancerInhibitorinhibitorinhibit

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目录号：
HY-150073
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