1. Neuronal Signaling
  2. Cholinesterase (ChE) Monoamine Oxidase
  3. Dual AChE-MAO B-IN-3

Dual AChE-MAO B-IN-3 (compound C10) 是一种有效的双 AChE/MAO-B 抑制剂,IC50 值分别为 0.58 和 0.41 μM。Dual AChE-MAO B-IN-3 是一种双结合抑制剂,能与 AChE 的催化阴离子位点和外周阴离子位点结合。Dual AChE-MAO B-IN-3 可以用于阿尔茨海默病 (AD) 的研究。

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Dual AChE-MAO B-IN-3 Chemical Structure

Dual AChE-MAO B-IN-3 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target

MAO-B

0.41 ± 0.0 μM (IC50)

EeAChE

0.58 ± 0.0 μM (IC50)

体外研究
(In Vitro)

Dual AChE-MAO B-IN-3 (compound C10) (0-100 μM, 24 h) exhibits low neurotoxicity, and (0-10 μM, 24 h) potently inhibits AChE enzymatic activity[1].
Dual AChE-MAO B-IN-3 more effectively protects against mitochondrial dysfunction and oxidation than Donepezil (HY-14566), strongly inhibits AChE-induced amyloid aggregation, and moderately reduces glutaraldehyde-induced phosphorylation of tau protein in SH-SY5Y cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 10 μM, 50 μM, 100 μM
Incubation Time: 24 h
Result: Exhibited a nonsignificant reduction in cell viabilities up to the maximum tested concentration of 100 μM. The percentage cell viability at 10-100 μM was observed in the range of 96.92−99.58%. Showed that compound C10 was not toxic to SH-SY5Y neuroblastoma cells at concentrations up to 100 μM.
体内研究
(In Vivo)

Dual AChE-MAO B-IN-3 (compound C10) (10 mg/kg, IP, once daily for 10 consecutive days) displays largely enhanced improvements in cognitive behaviors and spatial memory in a scopolamine-induced AD mice model with better efficacy than Donepezil (HY-14566)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (female, 8-10 weeks, 25-30 g)[1]
Dosage: 10 mg/kg
Administration: IP, once daily for 10 consecutive days
Result: Significantly ameliorated the cognitive impairment in a scopolamine-induced mice model.
分子量

505.53

Formula

C30H26F3NO3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Dual AChE-MAO B-IN-3 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Dual AChE-MAO B-IN-3
目录号:
HY-151885
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