2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. EG00229

EG00229 是 VEGF-A 和 NRP1 相互作用的抑制剂，IC50 为 8 μM。EG00229 可抑制 HUVECS 的迁移和内皮细胞中 VEGFR2 的磷酸化。EG00229 在癌细胞 A549 中表现出细胞毒性。

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EG00229

EG00229 Chemical Structure

CAS No. : 1018927-63-3

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EG00229 相关抗体

Top Publications Citing Use of Products

    EG00229 purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2017;44(3):1251-1262.  [Abstract]

    The inhibitor of NRP-1 called EG00229 decreases sphere and clone formation in MDA-MB-231 cells.

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    VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    EG00229 is an inhibitor for VEGF-A and NRP1 interaction with an IC50 of 8 μM. EG00229 inhibits the migration of HUVECS and the phosphorylation of VEGFR2 in endothelial cells. EG00229 exhibits cytotoxicity in cancer cell A549[1].

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    HEK293 IC50
    11.1 μM
    Compound: EG00229
    Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat
    Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat
    		[PMID: 31744780]
    分子量

    497.57

    Formula

    C17H19N7O5S3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    EG00229 相关分类

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    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    EG002291018927-63-3EG 00229EG-00229VEGFRVascular endothelial growth factor receptorA549DU145HUVECslung cancerprostate carcinomaInhibitorinhibitorinhibit

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    产品名称：
    EG00229
    目录号：
    HY-18333
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