2. Immunology/Inflammation
  3. CD276/B7-H3
  4. Enoblituzumab

Enoblituzumab  (Synonyms: 依诺妥珠单抗; MGA271)

目录号: HY-P9966 纯度: 99.16%
COA 技术支持

Enoblituzumab 是一种人源化 IgG1κ 单克隆抗体，可以识别人 B7-H3 蛋白 (B7 家族的免疫调节剂成员)。

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CAS No. : 1353485-38-7

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规格 价格 是否有货 数量
1 mg ￥2800
In-stock
5 mg 现货 询价
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Enoblituzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators[1].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

B7-H3/CD276
体外研究
(In Vitro)

Enoblituzumab 与 B7-H3 相互作用，并对多种癌细胞产生强效的抗体依赖性细胞毒作用 (ADCC)[2]。
Enoblituzumab (0.01 ng/mL-10 mg/mL) 介导食蟹猴外周血单核细胞 (PBMC) 对 A498 细胞产生抗体依赖性细胞毒作用 (ADCC)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enoblituzumab 相关抗体:
体内研究
(In Vivo)

Enoblituzumab (5 mg/kg；静脉注射；单剂量) 在小鼠 (mCD16-/-hCD16A+) 中的估计半衰期为 249 小时，Cmax 为 43 mg/mL，小鼠 CD16 基因被敲除，并且是人类 CD16A-158F[3]的转基因。
Enoblituzumab (0.1-10 mg/kg；静脉注射；每周一次；5 周) 在表达 B7-H3 的肾细胞癌和膀胱癌异种移植小鼠模型中表现出强效的抗肿瘤活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mCD16-/-hCD16A+ mice implanted with A498 renal cell carcinoma, 786-0 renal cell carcinoma, or HT-1197 bladder carcinoma cells (s.c.)[3]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Intravenous injection; once weekly; 5 weeks
Result: Significantly inhibited tumor growth at doses of 1 mg/kg or greater with once weekly treatment.
Achieved a cytostatic response at 5 or 10 mg/kg until day 52, after which the average tumor volume of the 5 mg/kg treatment group remained near predose administration levels, whereas a nonsignificant trend toward relapse exhibited in the 10 mg/kg group.
Clinical Trial
基因 ID

80381  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.1 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

依诺妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized CD276/B7-H3 Protein, Human can bind Enoblituzumab. The EC50 for this effect is 2.502 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Enoblituzumab (HY-P9966, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
纯度 & 产品资料

纯度: 99.16%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Enoblituzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enoblituzumab1353485-38-7MGA271依诺妥珠单抗MGA 271MGA-271CD276/B7-H3B7 homolog 3 proteinInhibitorinhibitorinhibit

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