2. Protein Tyrosine Kinase/RTK
  3. Syk
  4. ER-27319

ER-27319 是一种吖啶酮衍生物。ER-27319 是一种有效的选择性 SYK 抑制剂，可抑制 SYK 的酪氨酸磷酸化及其活性。ER-27319 抑制抗原诱导的过敏介质从人和大鼠肥大细胞中释放，IC50 值约为 10 μM。可用于过敏性疾病的研究。

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ER-27319 Chemical Structure

ER-27319 Chemical Structure

CAS No. : 201010-95-9

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规格 价格 是否有货 数量
5 mg ￥5573
3 - 4 周
10 mg   询价  
50 mg   询价  

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Other Forms of ER-27319:

ER-27319 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].

IC50 & Target

10 μM (Syk) in human and rat mast cells[1]
体外研究
(In Vitro)

ER-27319 (24 h) 抑制 RBL-2H3 细胞、大鼠腹膜和人培养肥大细胞中抗原诱导的肌醇磷酸的生成、花生四烯酸的释放、组胺和肿瘤坏死因子 α 的分泌，且IC50 值约为10 μM[1]。
ER-27319 (10-30 μM, 10 min) 选择性抑制 FcεRI γ 磷酸化的免疫受体酪氨酸激活基序诱导的 SYK 的酪氨酸磷酸化[1]。
ER-27319 (高达100 μM, 60 min) 不抑制Jurkat 细胞中 CD3 刺激引起的 ZAP-70 的酪氨酸磷酸化[1]。
ER-27319 (100 μM, 10 min) 在抗 IgG 刺激的犬皮肤瘤源性肥大细胞中抑制两种蛋白 (38, 70 kD) 的酪氨酸磷酸化，降低另外两种蛋白 (62, 80 kD) 的酪氨酸磷酸化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ER-27319 相关抗体:

Western Blot Analysis[1]

Cell Line: RBL-2H3 cells
Concentration: 10, 30 and 100 μM
Incubation Time: 10 min
Result: Inhibited the Tyrosine Phosphorylation of SYK in Mast Cells (the inhibition of 57% and 87% at 10 and 30 μM).
Inhibited the tyrosine phosphorylation of SYK induced by the phospho-γ ITAM of the FcεRI γ but not the tyrosine phosphorylation of Syk induced by the phospho-Ig β immunoreceptor tyrosine-based activation motif at 10 and 30 μM.
Had no effect on the Igβ immunoreceptor tyrosine-based activation motif-induced phosphorylation of SYK at 100 μM.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 3, 10, 30, 100 μM
Incubation Time: 10, 30, 60 min
Result: IDid not inhibit the the tyrosine phosphorylation of ZAP-70 in response to anti-CD3 stimulation.
分子量

370.40

Formula

C20H22N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ER-27319 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ER-27319201010-95-9ER27319ER 27319SykSpleen tyrosine kinaseRBL-2H3cultured human mast cellshuman peripheral B cellCanine cutaneous mastocytoma-derived cellsInhibitorinhibitorinhibit

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产品名称：
ER-27319
目录号：
HY-138961
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