2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Fungal
  4. Eupolauridine

Eupolauridine (Canangine) 是一种选择性的 DNA topoisomerase II 抑制剂，对真菌 topoisomerase I 的 IC50 值为 20 μM，对人 topoisomerase I 的 值为 33 μM。Eupolauridine 通过抑制拓扑异构酶 II 的催化活性，稳定其与 DNA 的切割复合物，导致 DNA 损伤，从而发挥抗真菌活性。Eupolauridine 有望用于真菌感染性疾病的研究。

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Eupolauridine Chemical Structure

Eupolauridine Chemical Structure

CAS No. : 58786-39-3

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Eupolauridine 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases[1][2].

IC50 & Target

Topoisomerase I

 

Topoisomerase II

 

分子量

204.23

同用名

Canangine

Formula

C14H8N2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eupolauridine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eupolauridine58786-39-3CanangineTopoisomeraseFungalDNA topoisomerase IItopoisomerase Ifungal infectious diseasesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-N15319
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