Topoisomerase Inhibitors

Topoisomerase

Topo I

Topo II

Topoisomerase Inhibitors & Agonists

Product Name	Topoisomerase	Topo I	Topo II	Purity
Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM	99.90%
Etoposide			Topoisomerase II	99.93%
Dxd		Topoisomerase I, IC₅₀: 0.31 μM		99.30%
SN-38		Topoisomerase I		99.94%
Telisotuzumab Adizutecan		Topoisomerase I		99.63%
Precemtabart tocentecan		Topoisomerase I		98.99%
Camptothecin		Topoisomerase I, IC₅₀: 679 nM		99.86%
Irinotecan		Topoisomerase I		99.97%
Topotecan hydrochloride		Topoisomerase I		99.89%
Datopotamab deruxtecan		Topoisomerase I		99.54%
Daunorubicin hydrochloride			Topoisomerase II	99.67%
Mitoxantrone			Topoisomerase II	99.58%
Irinotecan hydrochloride		Topoisomerase I		99.89%
Epirubicin hydrochloride	Topoisomerase			99.62%
Levofloxacin	TOPO IV			99.92%
Idarubicin hydrochloride			Topoisomerase II	99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM		99.06%
Mitoxantrone dihydrochloride			Topoisomerase II	98.98%
β-Lapachone		Topoisomerase I		99.96%
Etoposide phosphate			Topoisomerase II	99.44%
Dxd-d₅		Topoisomerase I, IC₅₀: 0.31 μM		98.89%
Teniposide			Topoisomerase II	99.00%
PNU-159682		Topoisomerase I		98.50%
Pirarubicin			Topoisomerase II	99.61%
Aldoxorubicin			Topoisomerase II
Belotecan hydrochloride		Top1		99.47%
Irinotecan hydrochloride trihydrate		Topoisomerase I		99.89%
Aclacinomycin A		Topoisomerase I	Topoisomerase II	99.30%
Nalidixic acid	Topoisomerase			99.97%
Aurintricarboxylic acid			Topoisomerase II
Levofloxacin hydrate	TOPO IV			99.98%
Ellipticine			Topoisomerase II	99.59%
Banoxantrone dihydrochloride			Topoisomerase II	99.46%
Pixantrone			Topoisomerase II	98.75%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM	99.74%
(S)-10-Hydroxycamptothecin		Topoisomerase I		99.74%
ICRF-193			Topoisomerase II	99.64%
Pirarubicin Hydrochloride			Topoisomerase II	99.14%
Amsacrine			Topoisomerase II	99.95%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM	99.69%
PluriSIn #2			topoisomerase II alpha	98.0%
Bisantrene			Topoisomerase II	98.06%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I		98.99%
Flumequine			Topoisomerase II, IC₅₀: 15 μM	99.65%
Epirubicin	Topoisomerase			99.11%
Amonafide			Topoisomerase II	99.92%
Ellipticine hydrochloride			Topoisomerase II	99.34%
Genz-644282		Topoisomerase I		99.13%
Hycanthone		Topoisomerase I	Topoisomerase II	99.81%
Coralyne chloride		Topoisomerase I		98.30%
MC-DOXHZN hydrochloride			Topoisomerase II	98.04%
Idarubicin			Topoisomerase II	99.89%
Voreloxin Hydrochloride			Topoisomerase II	99.58%
9-Aminocamptothecin		Topoisomerase I		98.89%
Amsacrine hydrochloride			Topoisomerase II	99.92%
Nalidixic acid sodium salt	Topoisomerase			99.83%
Isodiospyrin		Topoisomerase I		99.77%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II	98.45%
Indotecan		Topoisomerase I		98.0%
Amrubicin			Topoisomerase II	≥98.0%
Daun02	Topoisomerase			98.72%
Gimatecan		Topoisomerase I		99.28%
DACA		Topoisomerase I	Topoisomerase II	98.0%
LMP744		Top1		98.85%
ARN-21934			topoisomerase II alpha topoisomerase II beta	98.08%
LMP744 hydrochloride		Top1		99.08%
(±)-10-Hydroxycamptothecin		Topoisomerase I		99.57%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta	99.06%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL			99.78%
Tilatamig samrotecan		Topoisomerase I
VcMMAE-Deruxtecan		Topoisomerase I		98.10%
LMP517		Topoisomerase I	Topoisomerase II	99.58%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM	99.94%
Levofloxacin hydrochloride	TOPO IV			98.0%
Indimitecan		Top1		98.30%
(±)-Evodiamine		Top1		99.74%
Voreloxin			Topoisomerase II	99.26%
Daunorubicin			Topoisomerase II	98.20%
Intoplicine		Topoisomerase I	Topoisomerase II	98.36%
Karenitecin		Topoisomerase I		98.02%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM		99.62%
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM		98.65%
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)	99.50%
Namitecan		Topoisomerase I		98.03%
Topoisomerase II inhibitor 13			Topoisomerase II	98.07%
Lurtotecan		Topoisomerase I		98.01%
DS-3939a		Topoisomerase I
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
Topoisomerase I inhibitor 8		Topoisomerase I		99.87%
Topotecan		Topoisomerase I
Groenlandicine		Topoisomerase I		99.87%
Pefloxacin		Topoisomerase I		99.37%
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II	99.54%
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
9-Hydroxyellipticine hydrochloride			Topoisomerase II	99.0%
Topi MF-6		Top1
SW044248		Topoisomerase I		99.60%
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Deruxtecan-Eribulin		Topoisomerase I
20-O-Acetylcamptothecin		Topoisomerase I		≥98.0%
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM	98.44%
Zabofloxacin		Topoisomerase I	Topoisomerase II	98.02%
AQ4			Topoisomerase II
Edotecarin		Topoisomerase I, IC₅₀: 50 nM		98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM		98.71%
Amrubicin hydrochloride			Topoisomerase II	98.78%
Pixantrone free base			Topoisomerase II
Topovale		Topoisomerase I		99.94%
TAS-103		Topoisomerase I	Topoisomerase II
MC-DOXHZN			Topoisomerase II
AMT-562		Topoisomerase I
Topotecan hydrochloride hydrate		Topoisomerase I
Rebeccamycin		Topoisomerase I
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Etoposide phosphate disodium			Topoisomerase II
Antitumor agent-63		Top1
Daunorubicin citrate			Topoisomerase II
Mitoxantrone diacetate			Topoisomerase II
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
ZLHQ-5f		Top1
Nectandrin B		Topoisomerase I	Topoisomerase II
Razoxane			Topoisomerase II	99.16%
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
Topoisomerase I/II-IN-1		Topoisomerase I	Topoisomerase II
DTS-108		Top1
Topoisomerase II/EGFR-IN-1			Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
Niranthin	Topoisomerase
PBX-7016		Topoisomerase I
DBCO-PEG3-GGFG-Exatecan		Topoisomerase I
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6		Topoisomerase I
Corydamine		Topoisomerase I	Topoisomerase II
XSJ81		Topoisomerase I
DNA/TOP2A-IN-1			topoisomerase II alpha
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
GI-149893		Topoisomerase I
YCJ-02		Topoisomerase I
(Rac)-7-Ethyl-10-hydroxycamptothecin		Topoisomerase I
CS1			topoisomerase II alpha
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II-IN-24			topoisomerase II alpha, IC₅₀: 41.67 μM
T-2513 hydrochloride		Topoisomerase I
β-Glu-PAB(CH2NH2)-Exatecan	Topoisomerase
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
Topoisomerase II inhibitor 4			Topoisomerase II
Topoisomerase I inhibitor 17		Top1
Topoisomerase I inhibitor 12		Topoisomerase I
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Elomotecan		Topoisomerase I	Topoisomerase II
Salvicine			Topoisomerase II, IC₅₀: 3 μM
Camsirubicin			topoisomerase II beta
Silatecan		Topoisomerase I
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 7		Topoisomerase I	Topoisomerase II
Anticancer agent 276			Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
TP0480066			Topoisomerase II
MGB1Y		Topoisomerase I
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
KW-2170 hydrochloride			Topoisomerase II
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
Anticancer agent 75			Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II	98.28%
Anti-SLC34A2 (Lifastuzumab)-MC-Vc-PAB-SN38		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Heliquinomycin		Topoisomerase I	Topoisomerase II
MGB4		Topoisomerase I
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
(1R,9S)-Exatecan		Topoisomerase I
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
DBCO-PEG8-VKG-CPT2		Topoisomerase I
TP3011		Topoisomerase I
XSJ110		Topoisomerase I, IC₅₀: 0.133 μM
Topoisomerase IIα-IN-3			topoisomerase II alpha
Saintopin		Topoisomerase I	Topoisomerase II
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
Bimolane			Topoisomerase II
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
CP-67804			Topoisomerase II
Top/HDAC-IN-2		Top1	Topoisomerase II
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
T-2513		Topoisomerase I
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38		Topoisomerase I
NK-611			Topoisomerase II, IC₅₀: 56 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
(±)-E-Homocamptothecin		Topoisomerase I
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Topoisomerase IIα-IN-11			topoisomerase II alpha
Fmoc-Val-Cit-PAB-Exatecan		Topoisomerase I
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
LD2-3		Topoisomerase I
CP-67015			Topoisomerase II
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
RSK2/TOP2-IN-1			topoisomerase II alpha topoisomerase II beta
Topoisomerase I inhibitor 16		Topoisomerase I
Pixantrone hydrochloride			Topoisomerase II
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
ICRF-196			Topoisomerase II
Topo I/II-IN-2		Topoisomerase I	Topoisomerase II
IID432			Topoisomerase II
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
LE01		Topoisomerase I
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
8-Chloro-ATP tetrasodium			Topoisomerase II
Luotonin F			Topoisomerase II
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Eupolauridine		Topoisomerase I	Topoisomerase II
IKE16			Topoisomerase II, IC₅₀: 13.68 μM
Topoisomerase IIα-IN-5			topoisomerase II alpha
Bakuchicin			Topoisomerase II, IC₅₀: 404 μM
LD-38		Topoisomerase I
8-Chloro-ATP			Topoisomerase II
(-)-BO 2367			Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL
Thaspine acetate		Topoisomerase I	Topoisomerase II
NBTI 5463			Topoisomerase II
HU 331			Topoisomerase II
NK 314			topoisomerase II alpha
AZD5099			Topoisomerase II

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