2. Anti-infection Apoptosis
  3. EBV HSV Apoptosis
  4. Ferruginol

Ferruginol  (Synonyms: (+)-Ferruginol)

目录号: HY-N6033 纯度: 96.91%
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Ferruginol ((+)-Ferruginol) 是一种天然二萜类化合物，是 Epstein-Barr 病毒早期抗原 (EBV-EA) 激活的抑制剂。Ferruginol 通过诱导线粒体凋亡 (apoptosis) 抑制甲状腺癌细胞的生长。Ferruginol 具有抗肿瘤，心脏保护，抗氧化、胃保护和神经保护活性。

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Ferruginol

Ferruginol Chemical Structure

CAS No. : 514-62-5

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1 mg ￥2730
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Ferruginol 相关抗体

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HSV-1 HSV-2 HSV

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: 25
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 23691952]
A549 GI50
30.67 μM
Compound: 14
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
A549 ED50
6.47 μg/mL
Compound: ferruginol
Cytotoxicity against human A549 cells after 7 days by MTT assay
Cytotoxicity against human A549 cells after 7 days by MTT assay
[PMID: 9014350]
BXPC-3 GI50
21.14 μM
Compound: 14
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
HeLa IC50
64.9 μM
Compound: 1
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 26638041]
HepG2 IC50
> 40 μM
Compound: 19
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 20402524]
HL-60 IC50
> 40 μM
Compound: 25
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 23691952]
HL-60 IC50
> 40 μM
Compound: 19
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 20402524]
HL-60 GI50
27.33 μM
Compound: 14
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
HT-29 IC50
39.4 μM
Compound: 12
Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay
[PMID: 26905523]
HT-29 ED50
6.43 μg/mL
Compound: ferruginol
Cytotoxicity against human HT-29 cells after 7 days by MTT assay
Cytotoxicity against human HT-29 cells after 7 days by MTT assay
[PMID: 9014350]
Jurkat IC50
35.1 μM
Compound: 19
Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
[PMID: 20402524]
Jurkat IC50
48.2 μM
Compound: 1
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 26638041]
MCF7 IC50
> 40 μM
Compound: 25
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 23691952]
MCF7 ED50
23.42 μg/mL
Compound: ferruginol
Cytotoxicity against human MCF7 cells after 7 days by MTT assay
Cytotoxicity against human MCF7 cells after 7 days by MTT assay
[PMID: 9014350]
MIA PaCa-2 IC50
25.9 μM
Compound: 20
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
[PMID: 21775156]
MRC5 GI50
40.01 μM
Compound: 14
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PANC-1 GI50
41.13 μM
Compound: 14
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PC-3 GI50
56.45 μM
Compound: 14
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
SMMC-7721 IC50
> 40 μM
Compound: 25
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 23691952]
SW480 IC50
> 40 μM
Compound: 25
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
[PMID: 23691952]
U-937 IC50
19.7 μM
Compound: 19
Cytotoxicity against human U937 cells after 48 hrs by MTT assay
Cytotoxicity against human U937 cells after 48 hrs by MTT assay
[PMID: 20402524]
U-937 IC50
21.3 μM
Compound: 1
Cytotoxicity against human U937 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human U937 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 26638041]
Vero EC50
1.39 μM
Compound: 1
Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA
Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA
[PMID: 17663539]
Vero CC50
80.4 μM
Compound: 1
Cytotoxicity against Vero E6 cells by MTT assay
Cytotoxicity against Vero E6 cells by MTT assay
[PMID: 17663539]
Vero IC50
90.4 μM
Compound: 1
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 26638041]
体外研究
(In Vitro)

Ferruginol（0-160 μM；24 小时）对甲状腺癌细胞具有有效的抗增殖作用，对 MDA-T32 细胞系的 IC50 为 12 μM。Ferruginol 对正常细胞的毒性作用不太明显[1]。
Ferruginol（0-24 μM；24 小时）诱导 MDA-T32 细胞的凋亡性细胞死亡。Ferruginol 剂量依赖性地增加 Bax 表达并降低 Bcl-2 表达[1]。
Ferruginol（0-24 μM；24 小时）抑制 MDA-T32 细胞的 MAPK 和 PI3K/AKT 信号通路[1]。
Ferruginol（0-24 μM；24 小时）还会引起 ROS 介导的 MDA-T32 细胞基质金属蛋白酶改变[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferruginol 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-T32 cells
Concentration: 0-160 μM
Incubation Time: 24 hours
Result: Exerted potent antiproliferative action against thyroid cancer cells.

Apoptosis Analysis[1]

Cell Line: MDA-T32 cells
Concentration: 0 μM, 6 μM, 12 μM, and 24 μM
Incubation Time: 24 hours
Result: Induced apoptotic cell death of MDA-T32 cells

Western Blot Analysis[1]

Cell Line: MDA-T32 cells
Concentration: 0 μM, 6 μM, 12 μM, and 24 μM
Incubation Time: 24 hours
Result: Blocked the MAPK and PI3K/AKT signaling pathway.
体内研究
(In Vivo)

Ferruginol（20 mg/kg；口服；每天；持续 4 周）发挥心脏保护作用，表现为增强的心脏功能和减少的结构损伤和细胞凋亡。转录组和其他结果表明，Ferruginol 通过增加 PGC-1α 的表达并同时促进 SIRT1 增强脱乙酰酶 SIRT1 去乙酰化和激活 PGC-1α 的表达，促进 PGC-1α 介导的线粒体生物发生和脂肪酸氧化 (MB 和 FAO)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20 g, 8-10 weeks old) with Doxorubicin (DOX)-induced cardiotoxicity (DIC)[3].
Dosage: 20 mg/kg
Administration: Administered intragastrically; daily; for 4 weeks
Result: Relieved Doxorubicin-induced cardiac structural and functional lesion.
分子量

286.45

Formula

C20H30O
CAS 号
性状

固体

颜色

White to off-white

中文名称

弥罗松酚；铁锈醇
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Ferruginol 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferruginol514-62-5(+)-Ferruginol弥罗松酚铁锈醇EBVHSVApoptosisEpstein-Barr VirusHerpes simplex virusEBV-EAmitochondrial apoptosisantitumor and cardioprotective activitiesditerpenoidROSPI3K/AKTInhibitorinhibitorinhibit

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