1. Anti-infection Apoptosis
  2. EBV HSV Apoptosis
  3. Ferruginol

Ferruginol  (Synonyms: (+)-Ferruginol)

目录号: HY-N6033
产品使用指南

Ferruginol ((+)-Ferruginol) 是一种天然二萜类化合物,是 Epstein-Barr 病毒早期抗原 (EBV-EA) 激活的抑制剂。Ferruginol 通过诱导线粒体凋亡 (apoptosis) 抑制甲状腺癌细胞的生长。Ferruginol 具有抗肿瘤,心脏保护,抗氧化、胃保护和神经保护活性。

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Ferruginol Chemical Structure

Ferruginol Chemical Structure

CAS No. : 514-62-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3].

体外研究
(In Vitro)

Ferruginol(0-160 μM;24 小时)对甲状腺癌细胞具有有效的抗增殖作用,对 MDA-T32 细胞系的 IC50 为 12 μM。Ferruginol 对正常细胞的毒性作用不太明显[1]
Ferruginol(0-24 μM;24 小时)诱导 MDA-T32 细胞的凋亡性细胞死亡。Ferruginol 剂量依赖性地增加 Bax 表达并降低 Bcl-2 表达[1]
Ferruginol(0-24 μM;24 小时)抑制 MDA-T32 细胞的 MAPK 和 PI3K/AKT 信号通路[1]
Ferruginol(0-24 μM;24 小时)还会引起 ROS 介导的 MDA-T32 细胞基质金属蛋白酶改变[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-T32 cells
Concentration: 0-160 μM
Incubation Time: 24 hours
Result: Exerted potent antiproliferative action against thyroid cancer cells.

Apoptosis Analysis[1]

Cell Line: MDA-T32 cells
Concentration: 0 μM, 6 μM, 12 μM, and 24 μM
Incubation Time: 24 hours
Result: Induced apoptotic cell death of MDA-T32 cells

Western Blot Analysis[1]

Cell Line: MDA-T32 cells
Concentration: 0 μM, 6 μM, 12 μM, and 24 μM
Incubation Time: 24 hours
Result: Blocked the MAPK and PI3K/AKT signaling pathway.
体内研究
(In Vivo)

Ferruginol(20 mg/kg;口服;每天;持续 4 周)发挥心脏保护作用,表现为增强的心脏功能和减少的结构损伤和细胞凋亡。转录组和其他结果表明,Ferruginol 通过增加 PGC-1α 的表达并同时促进 SIRT1 增强脱乙酰酶 SIRT1 去乙酰化和激活 PGC-1α 的表达,促进 PGC-1α 介导的线粒体生物发生和脂肪酸氧化 (MB 和 FAO)[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20 g, 8-10 weeks old) with Doxorubicin (DOX)-induced cardiotoxicity (DIC)[3].
Dosage: 20 mg/kg
Administration: Administered intragastrically; daily; for 4 weeks
Result: Relieved Doxorubicin-induced cardiac structural and functional lesion.
分子量

286.45

Formula

C20H30O

CAS 号
中文名称

弥罗松酚;铁锈醇

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Ferruginol 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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