1. Apoptosis Anti-infection
  2. Apoptosis HSV HIV
  3. FK-3000

FK-3000 是一种有效的抗肿瘤剂,可通过细胞凋亡和诱导细胞周期停滞来抑制癌细胞的生长。FK-3000 还表现出针对 HSV-1HIV-1 的抗病毒作用。

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FK-3000 Chemical Structure

FK-3000 Chemical Structure

CAS No. : 1054312-81-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and HIV-1[1][2][3][4].

体外研究
(In Vitro)

FK-3000 (0-5 μg/mL; 48 h) 抑制细胞增殖,抑制 MDA-MB-231,MCF-7,PC-3,A-431,HT-29 和 CT-26细胞的 IC50 值分别为 0.52,0.77,0.22,2.70,0.40 和 1.90 μg/mL[1]
FK-3000 (0.5-5.0 μg/mL; 24-48 h) 以剂量和时间依赖性方式诱导 MDA-MB-231 细胞凋亡[1]
FK-3000 (0.5-5.0 μg/mL; 24-48 h) 以剂量和时间依赖性方式诱导 MDA-MB-231 和 MCF-7 细胞的 G2/M 期阻滞[2]
FK-3000 (0.5-5.0 μg/mL; 60-120 min or 24-48 h) 降低 MDA-MB-231 细胞中的 NF-κB 磷酸化水平和 COX-2 表达[1]
FK-3000 (5.0 μg/mL; 120 min) 有效阻断 MDA-MB-231 细胞中 NF-κB 从细胞质向细胞核的易位[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

FK-3000 (1 mg/kg/day; i.p. daily for 24 d) 抑制MDA-MB-231 异种移植小鼠模型中肿瘤生长,并且没有显示出毒性迹象[1]
FK-3000 (10-25 mg/kg; p.o. for 10 d) 显着延迟皮肤损伤,限制进一步损伤的发展并延长 HSV-1 感染小鼠的平均存活时间[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

417.45

Formula

C22H27NO7

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

FK-3000 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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FK-3000
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HY-N11097
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