2. Neuronal Signaling Metabolic Enzyme/Protease Epigenetics PI3K/Akt/mTOR Apoptosis Autophagy
  3. CaMK MMP AMPK Apoptosis Autophagy
  4. Fluoxetine-Conjugated Platinum(IV) prodrug-1

Fluoxetine-Conjugated Platinum(IV) prodrug-1 

目录号: HY-176149
产品使用指南 技术支持

Fluoxetine-Conjugated Platinum(IV) prodrug-1 (Compound 8) 是一种 eEF2K 抑制剂。Fluoxetine-Conjugated Platinum(IV) prodrug-1 可抑制癌细胞的增殖，诱导 DNA 损伤、细胞周期在 S 期阻滞和细胞凋亡 (Apoptosis)。Fluoxetine-Conjugated Platinum(IV) prodrug-1 诱导 ROS 积累和线粒体功能障碍。Fluoxetine-Conjugated Platinum(IV) prodrug-1 通过抑制 MMP-2 活性来抑制 TNBC 细胞迁移和侵袭。Fluoxetine-Conjugated Platinum(IV) prodrug-1 通过激活 AMPK 来诱导 TNBC 细胞自噬。Fluoxetine-Conjugated Platinum(IV) prodrug-1 在 4T1-Luc 小鼠模型中具有抗肿瘤活性并激活免疫抑制。Fluoxetine-Conjugated Platinum(IV) prodrug-1 可用于三阴乳腺癌 (TNBC) 的研究。

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Fluoxetine-Conjugated Platinum(IV) prodrug-1

Fluoxetine-Conjugated Platinum(IV) prodrug-1 Chemical Structure

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Fluoxetine-Conjugated Platinum(IV) prodrug-1 相关抗体

Top Publications Citing Use of Products

查看 CaMK 亚型特异性产品:

查看所有亚型
CaMK II CaMK III/eEF-2K CAMK IV PHK Trio DCAMKL

查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fluoxetine-Conjugated Platinum(IV) prodrug-1 (Compound 8) is an eEF2K inhibitor. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits cancer cell proliferation, induces DNA damage, cell cycle arrest at S phase and apoptosis. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces ROS accumulation and mitochondrial dysfunction. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits TNBC cell migration and invasion by inhibiting MMP-2 activity. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces autophagy in TNBC cells by activating AMPK. Fluoxetine-Conjugated Platinum(IV) prodrug-1 has antitumor activity and activates immunosuppression in the 4T1-Luc mouse model. Fluoxetine-Conjugated Platinum(IV) prodrug-1 can be used in triple-negative breast cancer (TNBC) research[1].

分子量

725.45

Formula

C21H28Cl2F3N3O5Pt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fluoxetine-Conjugated Platinum(IV) prodrug-1 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluoxetine-Conjugated Platinum(IV) prodrug-1CaMKMMPAMPKApoptosisAutophagyCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesMatrix metalloproteinasesAMP-activated protein kinaseTNBCMDA-MB-231MCF-7A549HCT-116HeLaHepG2LO24T1-Luc mouse modeltumorcancerInhibitorinhibitorinhibit

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