2. GPCR/G Protein Neuronal Signaling PI3K/Akt/mTOR Apoptosis
  3. Dopamine Receptor PI3K Apoptosis
  4. Flupentixol

Flupentixol  (Synonyms: Flupenthixol)

目录号: HY-15856A
产品使用指南

摩尔计算器

Flupentixol 是一种具有口服活性的 D1/D2 多巴胺受体拮抗剂和新型 PI3K 抑制剂 (PI3Kα IC50=127 nM)。Flupentixol 具有对癌细胞的抗增殖活性并诱导细胞凋亡。Flupentixol 也可用于精神分裂症、焦虑和抑郁症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flupentixol Chemical Structure

Flupentixol Chemical Structure

CAS No. : 2709-56-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Flupentixol 的其他形式现货产品:

Customer Review

Other Forms of Flupentixol:

Flupentixol 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research[1][2][3].

IC50 & Target[3]

D1 Receptor

 

D2 Receptor

 

PI3Kα

127 nM (IC50)

体外研究
(In Vitro)

Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner[3].
Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells[3].
Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flupentixol 相关抗体:

Cell Viability Assay[3]

Cell Line: A549, H661, SK-SEM-1, and NCAL-H520 cells
Concentration: 2.5, 5, 10, 20, or 40 μM
Incubation Time: 72 hours
Result: Showed the IC50s of 5.708 μM and 6.374 μM for A549 and H661 cells, respectively.

Apoptosis Analysis[3]

Cell Line: A549 and H661 cells
Concentration: 5, 10, 20 and 40 μM
Incubation Time: 24 hours
Result: Increased the percentage of cells in early apoptosis compared with the negative control in both A549 and H661 (p< 0.05). Induced the cleavage of PARP and caspase-3 in a dose-dependent manner.

Western Blot Analysis[3]

Cell Line: H661 and A549 cells
Concentration: 2.5, 5, 10, and 15 μM
Incubation Time: 24 hours
Result: Decreased AKT phosphorylation levels in a dose-dependent manner, decreased the expression levels of Bcl-2.
体内研究
(In Vivo)

Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C nude mice injected with A549 cells[3]
Dosage: 40 mg/kg
Administration: Intragastric injection; 40 mg/kg; once daily; 21 days
Result: Reduced tumor volumes compared to the vehicle control (p<0.05), reduced tumor weights by 64.1% (p<0.05).
Clinical Trial
分子量

434.52

Formula

C23H25F3N2OS
CAS 号
中文名称

氟哌噻吨
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Flupentixol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flupentixol2709-56-0Flupenthixol氟哌噻吨Dopamine ReceptorPI3KApoptosisPhosphoinositide 3-kinaseanti-proliferative activityinduce apoptosisschizophreniaanxiolyticdepressiveA549H661SK-SEM-1NCAL-H520Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Flupentixol
目录号：
HY-15856A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z