2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. Ganitumab

Ganitumab  (Synonyms: AMG 479; Human Anti-IGF1R Recombinant Antibody)

目录号: HY-P99294 纯度: 95.00%
COA

摩尔计算器

Ganitumab (AMG 479) 是一种重组人1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 识别具有亚纳米摩尔亲和力的小鼠 IGF1R (KD=0.22 nM)，并抑制小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用。Ganitumab 可用于癌症研究。

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Ganitumab Chemical Structure

Ganitumab Chemical Structure

CAS No. : 905703-97-1

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Ganitumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1].

体外研究
(In Vitro)

Ganitumab (AMG 479; 0.032-500 nM; 10 分钟; CT26 细胞) 结合 mIGF1R 并抑制 IGF1 和 IGF2 介导的 mIGF1R 的激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ganitumab 相关抗体:

Western Blot Analysis[1]

Cell Line: CT26 cells
Concentration: 0.032-500 nM
Incubation Time: 10 minutes
Result: Inhibited IGF1-induced autophosphorylation of mIGF1R in CT26 murine colon carcinoma cells in a dose-dependent manner.
体内研究
(In Vivo)

Ganitumab (AMG 479; 1 mg/剂; i.p; Naïve 和荷瘤小鼠) 抑制 IGF1 诱导的小鼠肺中 mIGF1R 的激活[1]。
Ganitumab (300 μg/剂; i.p.; 雌性无胸腺裸鼠) 减少外周血中性粒细胞[1]。
Ganitumab (300 μg/剂; i.p.;雄性无胸腺裸鼠) 导致雄性小鼠糖耐量受损，并增加血清中 mGH，mIGF1 和 mIGFBP3[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naïve and tumor-bearing mice[1]
Dosage: 1 mg/dose
Administration: Intraperitoneal injection
Result: Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth.
Animal Model: Male athymic nude mice[1]
Dosage: 300 μg/dose
Administration: Intraperitoneal injection, twice per week for a total of five doses
Result: Had significantly higher serum glucose levels than hIgG1-pretreated mice.
Increased serum levels of mIGF1, mIGFPB3 and mGH.
Animal Model: Female athymic nude mice[1]
Dosage: 300 μg/dose
Administration: Intraperitoneal injection, twice per week for a total of five doses
Result: Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Ganitumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganitumab905703-97-1AMG 479 Human Anti-IGF1R Recombinant AntibodyAMG479AMG-479IGF-1RInsulin-like growth factor-1 receptormonoclonal antibodycancerIGF1IGF2Inhibitorinhibitorinhibit

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