2. Immunology/Inflammation Apoptosis
  3. PD-1/PD-L1 Apoptosis
  4. Garivulimab

Garivulimab  (Synonyms: BGB-A333)

目录号: HY-P99633

摩尔计算器

Garivulimab (BGB-A333) 是一种人源化 IgG1 变体单克隆抗体，可特异性靶向并结合 PD-L1。Garivulimab 选择性地阻断 PD-L1 和 PD-1 的相互作用，具有抗肿瘤活性。

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Garivulimab Chemical Structure

Garivulimab Chemical Structure

CAS No. : 2342597-81-1

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Garivulimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

Garivulimab (BGB-A333) is a humanized IgG1-variant monoclonal antibody that specifically targets and binds to PD-L1. Garivulimab selectively blocks the interaction of PD-L1 and PD-1. Garivulimab has antitumor activity[1].

体外研究
(In Vitro)

Garivulimab (BGB-A333) 特异性靶向并结合 PD-L1，阻断与其受体 PD-1 在 T 细胞上的相互作用，逆转 T 细胞失活，并增加 T 细胞扩增，导致细胞毒性 T 细胞介导的针对 PD 的抗肿瘤免疫反应 -L1表达的肿瘤细胞。Garivulimab 还可抑制 PD-L1 诱导的活化 CD8+ T 细胞凋亡并增加 T 细胞增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Garivulimab 相关抗体:
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Garivulimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garivulimab2342597-81-1BGB-A333PD-1/PD-L1ApoptosisPD-1/Programmed death-ligand 1IgG1PD-L1 mAbantitumor activityT cellInhibitorinhibitorinhibit

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