2. Gene
  3. ACOT8 - acyl-CoA thioesterase 8 Gene

ACOT8 - acyl-CoA thioesterase 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酰基辅酶 A 硫酯酶 8

种属: Homo sapiens

同用名: hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III

基因 ID: 10005 | 基因类型: protein coding

关于 ACOT8

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,841,721-45,857,392 (from NCBI)

This gene has 13 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in adrenal (RPKM 10.6), brain (RPKM 10.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种过氧化物酶体硫酯酶，它似乎更多地参与脂肪酸的氧化而不是它们的形成。编码的蛋白质可以与人类免疫缺陷病毒 1 蛋白 Nef 结合，并介导 Nef 诱导的 T 细胞中 CD4 的下调。[RefSeq 提供，2010 年 10 月]

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

ACOT8 基因产物(1)

mRNA Protein Name
NM_005469.4 NP_005460.2 acyl-coenzyme A thioesterase 8

ACOT8 蛋白结构

4HBT_3

4HBT_3: Thioesterase-like superfamily (48 - 307)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
蛋白主名 其他名称

acyl-coenzyme A thioesterase 8

HIV-Nef associated acyl-CoA thioesterase

关联疾病

疾病名称 别名
Non-Syndromic X-Linked Intellectual Disability 14

Mrx14
Flinders Island Spotted Fever

Fisf

Thai Tick Typhus
Hypotrichosis 1

HYPT1

Hhs

Hts

Hypotrichosis Simplex

Hypotrichosis Simplex, Generalized, Hereditary

Hereditary Generalized Hypotrichosis Simplex

Generalized Hypothricosis Simplex

Hypotrichosis Simplex Hereditary

Hypotrichosis, Type 1
Alpha-Methylacyl-Coa Racemase Deficiency

Amacr Deficiency

AMACRD
Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders

Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

Disorders Of Peroxisome Biogenesis

Zellweger Spectrum

Zellweger Syndrome Spectrum

Peroxisomal Biogenesis Disorders

Pbd, Zss

Pbd-Zsd

Pbd-Zss

Pbd-Zellweger Spectrum Disorder

Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

Peroxisome Biogenesis Disorder

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorders

Zellweger Spectrum Disorder

Hyperpipecolic Acidaemia
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00180 ACOT8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ACOT8 VGNC VGNC:37519
Felis catus ACOT8 VGNC VGNC:59520
Bos taurus ACOT8 VGNC VGNC:25550
Rattus norvegicus ACOT8 RGD RGD:70368
Macaca mulatta ACOT8 VGNC VGNC:69413
Mus musculus ACOT8 MGD MGI:2158201
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