1. Gene
  2. NET1 - neuroepithelial cell transforming 1 Gene

NET1 - neuroepithelial cell transforming 1 Gene

中文名称:神经上皮细胞转化 1

种属: Homo sapiens

同用名: NET1A; ARHGEF8

基因 ID: 10276 | 基因类型: protein coding

关于 NET1

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,412,557-5,459,056 (from NCBI)

This gene has 6 transcripts (splice variants), 267 orthologues and 8 paralogues. Ubiquitous expression in colon (RPKM 43.6), small intestine (RPKM 31.5) and 25 other tissues.

功能概要

该基因是 Rho 鸟嘌呤核苷酸交换因子家族的一部分。该家族的成员通过催化 GDP 与 GTP 的交换来激活 Rho 蛋白。该基因编码的蛋白质与细胞核内的 RhoA 相互作用,可能在电离辐射后修复 DNA 损伤中发挥作用。该基因的假基因位于 1、7 和 18 号染色体的长臂上。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供,2012 年 7 月]

This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

NET1 基因产物(2)

mRNA Protein Name
NM_001047160.3 NP_001040625.1 neuroepithelial cell-transforming gene 1 protein isoform 1
NM_005863.5 NP_005854.2 neuroepithelial cell-transforming gene 1 protein isoform 2

NET1 蛋白结构

RhoGEF

RhoGEF: RhoGEF domain (179 - 354)

PH

PH: PH domain (394 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 596 a.a.
蛋白主名 其他名称

neuroepithelial cell-transforming gene 1 protein

Rho guanine nucleotide exchange factor (GEF) 8

关联疾病

疾病名称 别名
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus NET1 VGNC VGNC:32010
Mus musculus NET1 MGD MGI:1927138
Macaca mulatta NET1 VGNC VGNC:75176
Felis catus NET1 VGNC VGNC:63779
Rattus norvegicus NET1 RGD RGD:1305034
Canis familiaris NET1 VGNC VGNC:43747