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  2. PIAS3 - protein inhibitor of activated STAT 3 Gene

PIAS3 - protein inhibitor of activated STAT 3 Gene

中文名称:激活的 STAT 3 蛋白抑制因子

种属: Homo sapiens

同用名: ZMIZ5

基因 ID: 10401 | 基因类型: protein coding

关于 PIAS3

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,848,522-145,859,081 (from NCBI)

This gene has 9 transcripts (splice variants), 128 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 17.3), skin (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码 PIAS [激活 STAT 的蛋白抑制剂 (信号转导和转录激活因子) ] 转录调节剂家族的成员。该蛋白质充当 SUMO (小泛素样修饰剂) -E3 连接酶,催化 SUMO 蛋白质与特定靶底物的共价连接。它直接与几种转录因子结合,并阻断或增强它们的活性。该基因的可变剪接转录变体已被鉴定,但其中一些变体的全长性质尚未确定。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

PIAS3 基因产物(1)

mRNA Protein Name
NM_006099.3 NP_006090.2 E3 SUMO-protein ligase PIAS3

PIAS3 蛋白结构

PINIT

PINIT: PINIT domain (122 - 278)

zf-MIZ

zf-MIZ: MIZ/SP-RING zinc finger (323 - 371)

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  • 628 a.a.
蛋白主名 其他名称

E3 SUMO-protein ligase PIAS3

E3 SUMO-protein transferase PIAS3

关联疾病

疾病名称 别名
Unilateral Focal Polymicrogyria
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PIAS3 MGD MGI:1913126
Macaca mulatta PIAS3 VGNC VGNC:75811
Rattus norvegicus PIAS3 RGD RGD:708413
Bos taurus PIAS3 VGNC VGNC:32857
Felis catus PIAS3 VGNC VGNC:64160
Canis familiaris PIAS3 VGNC VGNC:44521