TESK2 - testis associated actin remodelling kinase 2 Gene

中文名称：睾丸相关肌动蛋白重塑激酶 2

种属: Homo sapiens

关于 TESK2

功能概要

该基因产物是一种丝氨酸/苏氨酸蛋白激酶，包含一个 N 末端蛋白激酶结构域，其结构类似于睾丸特异性蛋白激酶 1 和含有 LIM 基序的蛋白激酶 (LIMKs) 的激酶结构域。其整体结构与前者最为相关，表明它属于蛋白激酶 LIMK/TESK 家族的 TESK 亚群。该基因主要在睾丸和前列腺中表达。大鼠基因在睾丸中的发育表达模式表明该基因在减数分裂阶段和/或精子发生的早期阶段具有重要作用。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]