POLD3 - DNA polymerase delta 3, accessory subunit Gene

中文名称：DNA 聚合酶 delta 3，辅助亚基

种属: Homo sapiens

同用名: P66; P68; PPP1R128

基因 ID: 10714 | 基因类型: protein coding

关于 POLD3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,592,582-74,669,341 (from NCBI)

This gene has 10 transcripts (splice variants) and 37 orthologues. Ubiquitous expression in testis (RPKM 7.5), colon (RPKM 6.2) and 25 other tissues.

功能概要

该基因编码 DNA 聚合酶 delta 的 66-kDa 亚基。 DNA 聚合酶 delta 具有聚合酶和 3' 至 5' 核酸外切酶活性，在 DNA 复制和修复中起着关键作用。编码的蛋白质通过与其他亚基和持续增殖辅助因子增殖细胞核抗原 (PCNA) 的相互作用，在调节 DNA 聚合酶 delta 的活性中发挥作用。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 3 月]

This gene encodes the 66-kDa subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA Polymerase delta through interactions with Other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

POLD3 基因产物(2)

mRNA	Protein	Name
NM_001363597.2	NP_001350526.1	DNA polymerase delta subunit 3 isoform 2
NM_006591.3	NP_006582.1	DNA polymerase delta subunit 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15576034	GOA
enables protein-macromolecule adaptor activity	IPI IPI: 通过物理相互作用推断	11595739	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA biosynthetic process	IDA IDA: 通过直接分析推断	11595739	GOA
involved in DNA-templated DNA replication	IDA IDA: 通过直接分析推断	20334433	GOA
involved in error-prone translesion synthesis	IDA IDA: 通过直接分析推断	24449906	GOA
involved in nucleotide-excision repair, DNA gap filling	IMP IMP: 通过突变表型推断	20227374	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of delta DNA polymerase complex	IDA IDA: 通过直接分析推断	11595739	GOA
part of delta DNA polymerase complex	IPI IPI: 通过物理相互作用推断	12403614	GOA
part of zeta DNA polymerase complex	IDA IDA: 通过直接分析推断	22465957	GOA
part of zeta DNA polymerase complex	IPI IPI: 通过物理相互作用推断	24449906	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLD3 蛋白结构

CDC27

0
100
200
300
400
466 a.a.

蛋白主名

其他名称

DNA polymerase delta subunit 3

DNA polymerase delta subunit C

POLD3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	POLD3	Q15054	PCNA	Homo sapiens	P12004	Anti Tag CoIP	16000169
种属内	POLD3	Q15054	POLD2	Homo sapiens	P49005	Anti Bait CoIP	16000169
种属内	POLD3	Q15054	POLD2	Homo sapiens	P49005	Y2H	16000169

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Chronic Fatigue Syndrome

Myalgic Encephalomyelitis	Postviral Fatigue Syndrome
Cfs	Myalgic Encephalitis
Encephalomyelitis, Myalgic	Chronic Fatigue
Fatigue Syndrome, Chronic	Benign Myalgic Encephalomyelitis
Akureyri	Akureyri Disease
Cfs - [Chronic Fatigue Syndrome]	Epidemic Neuromyasthenia
Myalgic Encephalomyelitis Syndrome	Me - [Myalgic Encephalomyelitis]
Pvfs - [Postviral Fatigue Syndrome]	Neuromyasthenia
Iceland Disease	Icelandic Disease

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10821	POLD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21694	Pold3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28212	Pold3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	POLD3	VGNC	VGNC:33115
Macaca mulatta	POLD3	VGNC	VGNC:101381
Mus musculus	POLD3	MGD	MGI:1915217
Felis catus	POLD3	VGNC	VGNC:64283
Rattus norvegicus	POLD3	RGD	RGD:1312027
Canis familiaris	POLD3	VGNC	VGNC:44776

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLD3 - DNA polymerase delta 3, accessory subunit Gene

关于 POLD3

功能概要

POLD3 基因产物(2)

POLD3 蛋白结构

POLD3 蛋白互作信息

关联疾病

直系同源

热门区域

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POLD3 - DNA polymerase delta 3, accessory subunit Gene

关于 POLD3

功能概要

POLD3 基因产物(2)

POLD3 蛋白结构

POLD3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z