2. Gene
  3. Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Gene

Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ogtl; 1110038P24Rik; 4831420N21Rik

基因 ID: 108155 | 基因类型: protein coding

关于 Ogt

功能概要

Enables protein O-GlcNAc transferase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and regulation of gluconeogenesis. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in several cellular components, including euchromatin; neuronal cell body; and zymogen granule. Predicted to be part of Histone Acetyltransferase complex and protein N-acetylglucosaminyltransferase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]

Ogt 基因产物(2)

mRNA Protein Name
NM_001290535.1 NP_001277464.1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2
NM_139144.4 NP_631883.2 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
22878500 MGI
enables protein O-acetylglucosaminyltransferase activity IDA
IDA: 通过直接分析推断
21471514 MGI
enables protein O-acetylglucosaminyltransferase activity IMP
IMP: 通过突变表型推断
23395176 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17670746 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
23395176 MGI
involved in hemopoiesis IMP
IMP: 通过突变表型推断
33406421 MGI
involved in mitophagy IMP
IMP: 通过突变表型推断
33406421 MGI
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
23395176 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
28637651 MGI
involved in positive regulation of lipid biosynthetic process IDA
IDA: 通过直接分析推断
21471514 MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose IDA
IDA: 通过直接分析推断
21471514 MGI
acts upstream of or within protein O-linked glycosylation IDA
IDA: 通过直接分析推断
17670746 MGI
involved in regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
23395176 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
28143929 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEP
IEP: 通过表达模式推断
28143929 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: 通过突变表型推断
28143929 MGI
involved in regulation of synapse assembly IDA
IDA: 通过直接分析推断
28143929 MGI
involved in regulation of synapse assembly IEP
IEP: 通过表达模式推断
28143929 MGI
involved in regulation of synapse assembly IMP
IMP: 通过突变表型推断
28143929 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
28143929 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
28143929 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
28143929 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
21471514 MGI
is active in synapse IDA
IDA: 通过直接分析推断
28143929 MGI
is active in synapse IEP
IEP: 通过表达模式推断
28143929 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

O-GlcNAc transferase subunit p110

O-linked N-acetylglucosamine transferase 110 kDa subunit

Ogt 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ogt Q8CGY8 Tet2 Mus musculus Q4JK59
Anti Bait CoIP
23222540
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119738 OSMI-1 Inhibitor 99.90% 否
HY-114361 OSMI-4 Inhibitor 99.69% 否
HY-112174 UDP-GlcNAc disodium 99.92% 否
HY-145934 UDP-GalNAz disodium Substrate 99.78% 否
HY-145934A UDP-GlcNAz disodium Substrate 99.74% 否
HY-136282 ST045849 Inhibitor 99.82% 否
HY-139793 UDP-glucosamine disodium 99.43% 否
HY-135784 OSMI-2 Inhibitor 98.73% 否
HY-101548 OGT-IN-1 Inhibitor 98.14% 否
HY-119738A (Rac)-OSMI-1 Inhibitor 96.51% 否
HY-148113 PG 34 98.0% 否
HY-135785 OSMI-3 Inhibitor 99.08% 否
HY-125278 OGT-IN-4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ogt NCBI NCBI:8473
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