2. Gene
  3. Tet2 - tet methylcytosine dioxygenase 2 Gene

Tet2 - tet methylcytosine dioxygenase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ayu17-449; mKIAA1546; E130014J05Rik

基因 ID: 214133 | 基因类型: protein coding

关于 Tet2

功能概要

Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tet2 基因产物(2)

mRNA Protein Name
NM_001040400.2 NP_001035490.2 methylcytosine dioxygenase TET2 isoform 1
NM_001346736.1 NP_001333665.1 methylcytosine dioxygenase TET2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 5-methylcytosine dioxygenase activity IDA
IDA: 通过直接分析推断
19372391 MGI
enables 5-methylcytosine dioxygenase activity IMP
IMP: 通过突变表型推断
21057493 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23222540 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chromosomal 5-methylcytosine DNA demethylation, oxidation pathway IMP
IMP: 通过突变表型推断
21803851 MGI
acts upstream of or within cytosine metabolic process IMP
IMP: 通过突变表型推断
21803851 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: 通过突变表型推断
21803851 MGI
acts upstream of or within hemoglobin metabolic process IMP
IMP: 通过突变表型推断
21803851 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
21723200 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
21803851 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
18288583 MGI
acts upstream of or within liver morphogenesis IMP
IMP: 通过突变表型推断
21803851 MGI
involved in myeloid cell differentiation IMP
IMP: 通过突变表型推断
21057493 MGI
acts upstream of or within myeloid progenitor cell differentiation IMP
IMP: 通过突变表型推断
21803851 MGI
acts upstream of or within positive regulation of gene expression via chromosomal CpG island demethylation IDA
IDA: 通过直接分析推断
20639862 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23353889 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
18288583 MGI
involved in protein O-linked glycosylation IMP
IMP: 通过突变表型推断
23353889 MGI
acts upstream of or within spleen development IMP
IMP: 通过突变表型推断
21803851 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

methylcytosine dioxygenase TET2

probable methylcytosine dioxygenase TET2

tet oncogene 2

tet oncogene family member 2

Tet2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Tet2 Q4JK59 Ogt Mus musculus Q8CGY8
Anti Bait CoIP
23222540
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111558 Bobcat339 Inhibitor 99.44% 否
HY-111558A Bobcat339 hydrochloride Inhibitor 99.62% 否
HY-402410 TETi76 Inhibitor 97.49% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tet2 NCBI NCBI:54790
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