CHRM2 - cholinergic receptor muscarinic 2 Gene

中文名称：胆碱能受体毒蕈碱 2

种属: Homo sapiens

同用名: HM2

基因 ID: 1129 | 基因类型: protein coding

关于 CHRM2

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:136,868,652-137,020,213 (from NCBI)

This gene has 8 transcripts (splice variants), 261 orthologues and 25 paralogues. Biased expression in heart (RPKM 10.8), gall bladder (RPKM 5.9) and 3 other tissues.

功能概要

毒蕈碱性胆碱能受体属于更大的 G 蛋白偶联受体家族。这些受体的功能多样性由乙酰胆碱与这些受体的结合定义，包括细胞反应，例如腺苷酸环化酶抑制、磷酸肌醇变性和钾通道介导。毒蕈碱受体影响乙酰胆碱在中枢和周围神经系统中的许多作用。毒蕈碱性胆碱能受体 2 参与介导心动过缓和心肌收缩力下降。已针对该基因描述了多个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

CHRM2 基因产物(10)

mRNA	Protein	Name
NM_000739.3	NP_000730.1	muscarinic acetylcholine receptor M2
NM_001006626.3	NP_001006627.1	muscarinic acetylcholine receptor M2
NM_001006627.3	NP_001006628.1	muscarinic acetylcholine receptor M2
NM_001006628.3	NP_001006629.1	muscarinic acetylcholine receptor M2
NM_001006629.3	NP_001006630.1	muscarinic acetylcholine receptor M2
NM_001006630.2	NP_001006631.1	muscarinic acetylcholine receptor M2
NM_001006631.3	NP_001006632.1	muscarinic acetylcholine receptor M2
NM_001006632.3	NP_001006633.1	muscarinic acetylcholine receptor M2
NM_001378972.1	NP_001365901.1	muscarinic acetylcholine receptor M2
NM_001378973.1	NP_001365902.1	muscarinic acetylcholine receptor M2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled acetylcholine receptor activity	IDA IDA: 通过直接分析推断	24256733	GOA
enables arrestin family protein binding	IPI IPI: 通过物理相互作用推断	11566136	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: 通过直接分析推断	24256733	GOA
involved in response to virus	IEP IEP: 通过表达模式推断	16548883	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	11566136	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	24256733	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHRM2 蛋白结构

7tm_1

0
100
200
300
400
466 a.a.

蛋白主名

其他名称

muscarinic acetylcholine receptor M2

7TM receptor

CHRM2 抗体

目录号	产品名	应用	反应物种
HY-P82865	Muscarinic Acetylcholine Receptor M2 Antibody (YA2610)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Drug Dependence

Low Compliance Bladder

Overactive Bladder	Hyperactivity Of Bladder
Hypertonic Bladder	Hypertonicity Of Bladder
Low Bladder Compliance	Oab - [Overactive Bladder]

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Trichothiodystrophy 7, Nonphotosensitive

TTD7	Nonphotosensitive Trichothiodystrophy 7
Trichothiodystrophy 7, Non-Photosensitive

Intestinal Schistosomiasis

Schistosomiasis Japonica	Schistosomiasis Mansoni
Katayama Fever	Schistosoma Japonicum Infection
Schistosoma Mansoni Infectious Disease	Schistosomiasis

Premature Ovarian Failure 18

POF18	Primary Ovarian Insufficiency 18
Ovarian Failure, Premature, Type 18

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Functional Colonic Disease

Colonic Diseases, Functional

Colonic Pseudo-Obstruction

Primary Chronic Pseudo-Obstruction Of Colon

Substance Dependence

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N8728	Aposcopolamine		98.44%	否
HY-RS02661	CHRM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19417	Chrm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25908	Chrm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CHRM2	VGNC	VGNC:39232
Felis catus	CHRM2	VGNC	VGNC:60874
Macaca mulatta	CHRM2	VGNC	VGNC:80862
Rattus norvegicus	CHRM2	RGD	RGD:620023
Mus musculus	CHRM2	MGD	MGI:88397
Bos taurus	CHRM2	VGNC	VGNC:27319
Others	CHRM2	NCBI

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