RBPJL - recombination signal binding protein for immunoglobulin kappa J region like Gene

中文名称：免疫球蛋白κJ 区样重组信号结合蛋白

种属: Homo sapiens

同用名: RBPL; SUHL; RBPSUHL

基因 ID: 11317 | 基因类型: protein coding

关于 RBPJL

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,306,840-45,317,824 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 1 paralogue. Restricted expression toward pancreas (RPKM 78.6).

功能概要

该基因编码无毛蛋白家族抑制因子的一个成员。小鼠中的一种类似蛋白质是一种转录因子，它结合的 DNA 序列几乎与 Notch 受体信号通路转录因子重组结合蛋白 J 结合的序列相同。小鼠蛋白质已被证明可激活与 Epstein-Barr 病毒核抗原一致的转录-2。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RBPJL 基因产物(3)

mRNA	Protein	Name
NM_001281448.2	NP_001268377.1	recombining binding protein suppressor of hairless-like protein isoform 2
NM_001281449.2	NP_001268378.1	recombining binding protein suppressor of hairless-like protein isoform 3
NM_014276.4	NP_055091.2	recombining binding protein suppressor of hairless-like protein isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBPJL 蛋白结构

LAG1-DNAbind

BTD

0
100
200
300
400
517 a.a.

蛋白主名

其他名称

recombining binding protein suppressor of hairless-like protein

transcription factor RBP-L

RBPJL 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RBPJL	Q9UBG7	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	RBPJL	Q9UBG7	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Spontaneous Ocular Nystagmus

Visual Deprivation Nystagmus	Ocular Nystagmus
Searching Eye Movements	Nystagmus, Pathologic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11773	RBPJL Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RBPJL	VGNC	VGNC:57020
Canis familiaris	RBPJL	VGNC	VGNC:54727
Macaca mulatta	RBPJL	VGNC	VGNC:84535
Felis catus	RBPJL	VGNC	VGNC:81169
Rattus norvegicus	RBPJL	RGD	RGD:1304786
Mus musculus	RBPJL	MGD	MGI:1196616

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RBPJL - recombination signal binding protein for immunoglobulin kappa J region like Gene

关于 RBPJL

功能概要

RBPJL 基因产物(3)

RBPJL 蛋白结构

RBPJL 蛋白互作信息

关联疾病

直系同源

热门区域

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RBPJL - recombination signal binding protein for immunoglobulin kappa J region like Gene

关于 RBPJL

功能概要

RBPJL 基因产物(3)

RBPJL 蛋白结构

RBPJL 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z