2. Gene
  3. Sqstm1 - sequestosome 1 Gene

Sqstm1 - sequestosome 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Osi; ZIP; ZIP3

基因 ID: 113894 | 基因类型: protein coding

关于 Sqstm1

功能概要

Enables identical protein binding activity and protein kinase C binding activity. Involved in positive regulation of protein phosphorylation and response to ischemia. Located in Lewy body and mitochondrion. Biomarker of glaucoma and hypertension. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2022]

Sqstm1 基因产物(5)

mRNA Protein Name
NM_001393884.1 NP_001380813.1 sequestosome-1 isoform 3
NM_001393885.1 NP_001380814.1 sequestosome-1 isoform 4
NM_001393886.1 NP_001380815.1 sequestosome-1 isoform 5
NM_175843.5 NP_787037.2 sequestosome-1 isoform 1
NM_181550.2 NP_853528.2 sequestosome-1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
10477520 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
10477520 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
23782269 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Lewy body IDA
IDA: 通过直接分析推断
15158159 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
28231469 RGD
is active in synapse IDA
IDA: 通过直接分析推断
28231469 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sequestosome-1

PKC-zeta-interacting protein

oxidative stress induced

protein kinase C-zeta-interacting protein

ubiquitin-binding protein p62

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112698 CA-5f 99.14% 否
HY-117469 Triptohypol C 96.56% 否
HY-RS13745 SQSTM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-169387 YT 6-2-PEG3-C2-NH2 Control 99.50% 否
HY-152100 CUR5g Inhibitor 98.69% 否
HY-169385 ATC-324 Degrader / 否
HY-169386 YT 6-2 analog-1 Control / 否
HY-169388 YT 6-2 Control / 否
HY-RS17351 Sqstm1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23805 Sqstm1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sqstm1 NCBI NCBI:8878
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