Acvr1b - activin A receptor, type 1B Gene

中文名称：激活素 A 受体，1B 型

种属: Mus musculus

同用名: Alk4; SKR2; ALK-4; ActRIB; ActR-IB; Acvrlk4; 6820432J04

关于 Acvr1b

功能概要

该基因编码的蛋白可启动激活素结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与肽基-苏氨酸磷酸化。作用于多个过程的上游或内部，包括激活素受体信号通路；毛囊发育；和基因表达的调控。预测位于细胞表面和胞质溶胶中。预计是质膜的组成部分。预计是激活素受体复合物的一部分。预计在质膜上有活性。以多种结构表达，包括消化系统；中枢神经系统;蛋筒；呼吸系统;和感觉器官。该基因的人类直系同源物与胰腺癌有关。与人类 ACVR1B（1B 型激活素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables activin binding activity and protein serine/threonine kinase activity. Involved in peptidyl-threonine phosphorylation. Acts upstream of or within several processes, including activin receptor signaling pathway; hair follicle development; and regulation of gene expression. Predicted to be located in cell surface and cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ACVR1B (Activin A receptor type 1B). [provided by Alliance of Genome Resources, Apr 2022]