2. Gene
  3. GBP5 - guanylate binding protein 5 Gene

GBP5 - guanylate binding protein 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：鸟苷酸结合蛋白 5

种属: Homo sapiens

同用名: GBP-5

基因 ID: 115362 | 基因类型: protein coding

关于 GBP5

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,256,189-89,272,860 (from NCBI)

This gene has 5 transcripts (splice variants), 98 orthologues and 10 paralogues. Biased expression in appendix (RPKM 33.2), lymph node (RPKM 19.8) and 11 other tissues.

功能概要

该基因属于 TRAFAC 类发动蛋白样 GTPase 超家族。编码的蛋白质充当 NLRP3 炎性体组装的激活剂，并在先天免疫和炎症中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 1 月]

This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

GBP5 基因产物(3)

mRNA Protein Name
NM_001134486.4 NP_001127958.1 guanylate-binding protein 5 isoform 1
NM_001391920.1 NP_001378849.1 guanylate-binding protein 5 isoform 2
NM_052942.5 NP_443174.1 guanylate-binding protein 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
26996307 GOA
enables endopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
31091448 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables molecular function inhibitor activity IDA
IDA: 通过直接分析推断
31091448 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21151871 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
21151871 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to type II interferon IEP
IEP: 通过表达模式推断
17266443 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
26996307 GOA
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: 通过直接分析推断
22461501 GOA
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
22461501 GOA
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
22461501 GOA
involved in protein localization to Golgi apparatus IDA
IDA: 通过直接分析推断
21151871 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Golgi apparatus IDA
IDA: 通过直接分析推断
26996307 GOA
located in Golgi apparatus IDA
IDA: 通过直接分析推断
17266443 GOA
is active in Golgi membrane IDA
IDA: 通过直接分析推断
31091448 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17266443 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
21151871 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GBP5 蛋白结构

GBP

GBP: Guanylate-binding protein, N-terminal domain (18 - 280)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (282 - 573)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 586 a.a.
蛋白主名 其他名称

guanylate-binding protein 5

GBP-TA antigen

GBP5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GBP5 Q96PP8 GBP4 Homo sapiens Q96PP9
Anti Tag CoIP
21151871
种属内
GBP5 Q96PP8 GBP4 Homo sapiens Q96PP9
BiFC
21151871
种属内
GBP5 Q96PP8 GBP3 Homo sapiens Q9H0R5
BiFC
21151871
种属内
GBP5 Q96PP8 GBP3 Homo sapiens Q9H0R5
Anti Tag CoIP
21151871
种属内
GBP5 Q96PP8 GBP1 Homo sapiens P32455
BiFC
21151871
种属内
GBP5 Q96PP8 GBP1 Homo sapiens P32455
Anti Tag CoIP
21151871
种属内
GBP5 Q96PP8 GBP1 Homo sapiens P32455
Anti Tag CoIP
33961781
种属内
GBP5 Q96PP8 GBP1 Homo sapiens P32455
Anti Tag CoIP
28514442
种属内
GBP5 Q96PP8 GBP2 Homo sapiens P32456
BiFC
21151871
种属内
GBP5 Q96PP8 GBP2 Homo sapiens P32456
Anti Tag CoIP
21151871
种属内
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
GMS
20180847
种属内
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
BiFC
21151871
种属内
GBP5 Q96PP8 ACSM1 Homo sapiens Q08AH1
Anti Tag CoIP
33961781
种属内
GBP5 Q96PP8 APOL2 Homo sapiens Q9BQE5
Anti Tag CoIP
33961781
种属内
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
Y2H Pooling
16189514
种属内
GBP5 Q96PP8 ACSM1 Homo sapiens Q08AH1
Anti Tag CoIP
28514442
种属内
GBP5 Q96PP8 APOL2 Homo sapiens Q9BQE5
Anti Tag CoIP
28514442
种属内
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
Anti Tag CoIP
21151871
种属内
GBP5 Q96PP8 GBP5 Homo sapiens Q96PP8
Y2H
21151871
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05311 GBP5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18761 Gbp5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25248 Gbp5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GBP5 RGD RGD:1311040
Mus musculus GBP5 MGD MGI:2429943
Bos taurus GBP5 VGNC VGNC:59183
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