2. Gene
  3. LEO1 - LEO1 homolog, Paf1/RNA polymerase II complex component Gene

LEO1 - LEO1 homolog, Paf1/RNA polymerase II complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LEO1 同源物，Paf1/RNA 聚合酶 II 复合物成分

种属: Homo sapiens

同用名: RDL

基因 ID: 123169 | 基因类型: protein coding

关于 LEO1

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:51,938,025-51,971,778 (from NCBI)

This gene has 3 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in colon (RPKM 10.8), urinary bladder (RPKM 9.3) and 25 other tissues.

功能概要

LEO1、parafibromin (CDC73; MIM 607393) 、CTR9 (MIM 609366) 和 PAF1 (MIM 610506) 形成与 RNA 聚合酶 II 亚基 POLR2A (MIM 180660) 和组蛋白甲基转移酶复合物 (Rozenblatt-Rosen) 结合的 PAF 蛋白复合物等人，2005 [PubMed 15632063]) 。[OMIM 提供，2008 年 3 月]

LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a Histone Methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]

LEO1 基因产物(4)

mRNA Protein Name
NM_001286430.2 NP_001273359.1 RNA polymerase-associated protein LEO1 isoform 2
NM_001323903.2 NP_001310832.1 RNA polymerase-associated protein LEO1 isoform 3
NM_001323904.2 NP_001310833.1 RNA polymerase-associated protein LEO1 isoform 4
NM_138792.4 NP_620147.1 RNA polymerase-associated protein LEO1 isoform 1

LEO1 蛋白结构

Leo1

Leo1: Leo1-like protein (373 - 537)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
蛋白主名 其他名称

RNA polymerase-associated protein LEO1

Leo1 Paf1/RNA polymerase II complex component

关联疾病

疾病名称 别名
Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone
Chiasmal Syndrome

Chiasma Syndrome

Disorder Of Optic Chiasm

Optic Chiasm Disorder

Chiasmal Optic Disorder

Disease Of Optic Chiasm

Chiasmal Lesion

Intrachiasmal Lesion

Prechiasmal Lesion
Hereditary Wilms' Tumor

Hereditary Wilms Tumor

Hereditary Wilms Tumour

Hereditary Wilms' Tumour

Wt1
Branchiootorenal Syndrome 1

Melnick-Fraser Syndrome

BOR1

Branchiootorenal Dysplasia

Branchiootorenal Syndrome 1, With Or Without Cataracts

Bor Syndrome 1

Branchiootorenal Dysplasia 1

Branchio-Oto-Renal Dysplasia 1

Branchio-Oto-Renal Syndrome Type 1

Branchiootorenal Syndrome, With/Without Cataract, Type 1

Branchio-Oto-Renal Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07592 LEO1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LEO1 MGD MGI:2685031
Rattus norvegicus LEO1 RGD RGD:1549772
Canis familiaris LEO1 VGNC VGNC:59117
Felis catus LEO1 VGNC VGNC:63214
Bos taurus LEO1 VGNC VGNC:30841
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