Ctsb - cathepsin B Gene

中文名称：组织蛋白酶 B

种属: Mus musculus

同用名: CB

关于 Ctsb

功能概要

该基因编码肽酶 C1 家族的成员和前原蛋白，后者经过蛋白水解处理可产生多种蛋白质产物。这些产品包括组织蛋白酶 B 轻链和重链，它们可以二聚化生成酶的双链形式。这种酶是一种溶酶体半胱氨酸蛋白酶，具有内肽酶和外肽酶活性，可能在蛋白质周转中发挥作用。该基因的纯合基因敲除小鼠在诱导性胰腺炎后表现出胰腺损伤减少，并且在肝损伤模型中肝细胞凋亡减少。已在基因组中鉴定出该基因的假基因。 [RefSeq 提供，2015 年 8 月]

This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the Cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the Enzyme. This Enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte Apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]