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  2. GNPDA2 - glucosamine-6-phosphate deaminase 2 Gene

GNPDA2 - glucosamine-6-phosphate deaminase 2 Gene

中文名称:6-磷酸氨基葡萄糖脱氨酶 2

种属: Homo sapiens

同用名: GNP2; SB52

基因 ID: 132789 | 基因类型: protein coding

关于 GNPDA2

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:44,701,795-44,726,556 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 8.8), thyroid (RPKM 8.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种变构酶,可催化将 D-葡萄糖胺-6-磷酸转化为 D-果糖-6-磷酸和铵的可逆反应。据报道,该基因的变异与影响体重指数和肥胖易感性有关。该基因的假基因位于 9 号染色体上。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供,2012 年 8 月]

The protein encoded by this gene is an allosteric Enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GNPDA2 基因产物(3)

mRNA Protein Name
NM_001270880.2 NP_001257809.1 glucosamine-6-phosphate isomerase 2 isoform 2
NM_001270881.2 NP_001257810.1 glucosamine-6-phosphate isomerase 2 isoform 3
NM_138335.3 NP_612208.1 glucosamine-6-phosphate isomerase 2 isoform 1

GNPDA2 蛋白结构

Glucosamine_iso

Glucosamine_iso: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase (14 - 216)

  • 0
  • 100
  • 200
  • 276 a.a.
蛋白主名 其他名称

glucosamine-6-phosphate isomerase 2

glcN6P deaminase 2

直系同源

种属 基因名 来源 基因 ID
Mus musculus GNPDA2 MGD MGI:1915230
Bos taurus GNPDA2 VGNC VGNC:29477
Felis catus GNPDA2 VGNC VGNC:62631
Macaca mulatta GNPDA2 VGNC VGNC:72978
Canis familiaris GNPDA2 VGNC VGNC:41332
Rattus norvegicus GNPDA2 RGD RGD:1305521
Others GNPDA2 NCBI