GPR151 - G protein-coupled receptor 151 Gene

中文名称：G 蛋白偶联受体 151

种属: Homo sapiens

同用名: GPCR; PGR7; GALR4; GALRL; GPCR-2037

关于 GPR151

功能概要

该基因编码 G 蛋白偶联受体 (GPCR) A 类视紫红质样家族的孤儿成员。在类视紫红质家族中，该基因是 SOG 亚家族的成员，该亚家族包括生长抑素、阿片样物质、甘丙肽和 kisspeptin 受体。直系同源小鼠基因具有神经元表达的受限模式，这是在神经损伤后诱导的。所有 GPCR 都有一个跨膜结构域，其中包括七个跨膜 α 螺旋。 GPCR 信号的一般特征是激动剂诱导的受体构象变化，导致异源三聚体 G 蛋白的激活。然后活化的 G 蛋白结合并激活许多下游效应蛋白，这些效应蛋白产生第二信使，介导广泛的细胞和生理过程。[RefSeq 提供，2017 年 7 月]

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, Galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]