2. Gene
  3. Egr1 - early growth response 1 Gene

Egr1 - early growth response 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: egr; TIS8; Zenk; Egr-1; NGFIA; Zfp-6; ETR103; Krox-1; Krox24; NGF1-A; NGFI-A; Zif268; Krox-24; A530045N19Rik

基因 ID: 13653 | 基因类型: protein coding

关于 Egr1

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to gamma radiation; regulation of gene expression; and regulation of hormone biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]

Egr1 基因产物(1)

mRNA Protein Name
NM_007913.5 NP_031939.1 early growth response protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
18323529 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20018936 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
8336701 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
12689920 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20018936 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15958557 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
8336701 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
31467272 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
18281035 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
8769660 MGI
acts upstream of or within T cell differentiation IMP
IMP: 通过突变表型推断
12165491 MGI
involved in cellular response to gamma radiation IMP
IMP: 通过突变表型推断
19057511 MGI
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
26471974 MGI
involved in circadian temperature homeostasis IMP
IMP: 通过突变表型推断
29138967 MGI
involved in estrous cycle IMP
IMP: 通过突变表型推断
8703054 MGI
involved in locomotor rhythm IMP
IMP: 通过突变表型推断
29138967 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
18281035 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16033766 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7720589 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17202132 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
26471974 MGI
involved in positive regulation of chemokine production IMP
IMP: 通过突变表型推断
11100120 MGI
involved in positive regulation of gene expression via chromosomal CpG island demethylation IGI
IGI: 通过遗传相互作用推断
31467272 MGI
involved in positive regulation of hormone biosynthetic process IMP
IMP: 通过突变表型推断
8703054 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
11100120 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20018936 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
8336701 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
12165491 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: 通过突变表型推断
23277542 MGI
involved in regulation of progesterone biosynthetic process IMP
IMP: 通过突变表型推断
8703054 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18323529 MGI
involved in response to glucose IDA
IDA: 通过直接分析推断
12689920 MGI
involved in response to hypoxia IMP
IMP: 通过突变表型推断
11100120 MGI
involved in response to insulin IDA
IDA: 通过直接分析推断
12689920 MGI
involved in response to ischemia IMP
IMP: 通过突变表型推断
11100120 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: 通过突变表型推断
22147266 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
8668170 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

early growth response protein 1

Krox-24 nuclear protein

nerve growth factor-induced protein A

transcription factor Zif268

zinc finger protein Krox-24

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-157549 Brivoligide / Phase 2
HY-121246 Fluorofenidone Inhibitor 99.78% Phase 1
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163731 EGR-1-IN-1 Inhibitor 98.11% 否
HY-116818 Crebinostat Inhibitor 99.79% 否
HY-169118 EGR-1-IN-2 Inhibitor 99.61% 否
HY-170415 EGR-1-IN-3 Inhibitor 99.13% 否
HY-146411 microRNA-21-IN-1 98.03% 否
HY-157549A Brivoligide sodium / 否
HY-RS04215 EGR1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-125980 LX-3 Inhibitor 98.08% 否
HY-131721 14,15-EET-SI Activator / 否
HY-121246S Fluorofenidone-d3 Inhibitor / 否
HY-RS16606 Egr1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23040 Egr1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Egr1 NCBI NCBI:1958
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