2. Gene
  3. BTLA - B and T lymphocyte associated Gene

BTLA - B and T lymphocyte associated Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：B 和 T 淋巴细胞相关

种属: Homo sapiens

同用名: BTLA1; CD272

基因 ID: 151888 | 基因类型: protein coding

关于 BTLA

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,463,966-112,499,624 (from NCBI)

This gene has 4 transcripts (splice variants) and 87 orthologues. Biased expression in lymph node (RPKM 5.9), appendix (RPKM 3.2) and 7 other tissues.

功能概要

该基因编码免疫球蛋白超家族的一个成员。编码的蛋白质包含单个免疫球蛋白 (Ig) 结构域，是一种传递抑制信号以抑制免疫反应的受体。可变剪接导致多个转录本变体。该基因的多态性与类风湿性关节炎风险增加有关。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

BTLA 基因产物(2)

mRNA Protein Name
NM_001085357.2 NP_001078826.1 B- and T-lymphocyte attenuator isoform 2
NM_181780.4 NP_861445.4 B- and T-lymphocyte attenuator isoform 1 precursor

BTLA 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (47 - 131)

  • 0
  • 100
  • 200
  • 289 a.a.
蛋白主名 其他名称

B- and T-lymphocyte attenuator

B- and T-lymphocyte-associated protein

重组 BTLA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7678 BTLA/CD272 Protein, Human (HEK293, His) Q7Z6A9-2 (K31-L198) ≥95%
HY-P7679 BTLA/CD272 Protein, Human (168a.a, HEK293, Fc) Q7Z6A9-2 (K31-L198) ≥95%
HY-P72030 BTLA/CD272 Protein, Human (HEK293, hFc-Myc) Q7Z6A9 (K31-S150) ≥95%
HY-P72858 BTLA/CD272 Protein, Human (104a.a, HEK293, Fc) Q7Z6A9-2 (K31-T134) ≥95%
HY-P78078 BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi) Q7Z6A9 (K31-S150) ≥95%
HY-P78394 BTLA/CD272 Protein, Human (HEK293, His-Avi) Q7Z6A9 (K31-S150) ≥95%
HY-P78924 BTLA/CD272 Protein, Human (Biotinylated, HEK293, Fc-Avi) AAP44003 (K31-S150) ≥95%

关联疾病

疾病名称 别名
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-108813 Belatacept Inhibitor 98.00% 否
Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99961 Tifcemalimab Inhibitor 95.00% Phase 3
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01669 BTLA Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BTLA RGD RGD:1303280
Canis familiaris BTLA VGNC VGNC:38561
Macaca mulatta BTLA VGNC VGNC:70358
Bos taurus BTLA VGNC VGNC:26602
Felis catus BTLA VGNC VGNC:60206
Mus musculus BTLA MGD MGI:2658978
Others BTLA NCBI
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