2. Gene
  3. Hoxb8 - homeobox B8 Gene

Hoxb8 - homeobox B8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hox-2.4

基因 ID: 15416 | 基因类型: protein coding

关于 Hoxb8

功能概要

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of myeloid cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dorsal spinal cord development; embryonic skeletal system morphogenesis; and grooming behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; nervous system; and neural ectoderm. Used to study trichotillomania. Orthologous to human HOXB8 (homeobox B8). [provided by Alliance of Genome Resources, Apr 2022]

Hoxb8 基因产物(1)

mRNA Protein Name
NM_010461.2 NP_034591.1 homeobox protein Hox-B8
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15886193 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20211142 MGI
enables sequence-specific DNA binding IMP
IMP: 通过突变表型推断
11571641 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
10559485 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
10885747 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
10559485 MGI
acts upstream of or within dorsal spinal cord development IMP
IMP: 通过突变表型推断
10559485 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
10885747 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: 通过突变表型推断
10559485 MGI
acts upstream of or within grooming behavior IMP
IMP: 通过突变表型推断
11779477 MGI
involved in negative regulation of myeloid cell differentiation IDA
IDA: 通过直接分析推断
11438208 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15886193 MGI
acts upstream of or within sensory perception of pain IMP
IMP: 通过突变表型推断
18430798 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
11311170 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: 通过突变表型推断
11311170 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

homeobox protein Hox-B8

homeo box B8

homeobox protein Hox-2.4

Hoxb8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Hoxb8 P09632 Pbx1 Mus musculus P41778
Y2H Array
20211142
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06312 HOXB8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22561 Hoxb8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29081 Hoxb8 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hoxb8 NCBI NCBI:3218
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