2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. Vimirogant

Vimirogant  (Synonyms: VTP-43742)

目录号: HY-103637
产品使用指南

摩尔计算器

Vimirogant (VTP-43742) 是一种选择性、具有口服活性的的 RORγt 抑制剂 (Ki=3.5 nM; IC50=17 nM)。Vimirogant 与 RORα 和 RORβ 比，高出 >1000 倍的选择性。Vimirogant 抑制小鼠脾细胞的 Th17 分化和 IL-17A 分泌 (IC50=57 nM)，而不会影响 Th1，Th2 或 Treg 细胞的分化。Vimirogant 可用于研究自身免疫性疾病研究。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Vimirogant hydrochloride。

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Vimirogant Chemical Structure

Vimirogant Chemical Structure

CAS No. : 1802706-04-2

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规格 是否有货
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Vimirogant 的其他形式现货产品:

Customer Review

Other Forms of Vimirogant:

Vimirogant 相关抗体

Top Publications Citing Use of Products

查看 ROR 亚型特异性产品:

查看所有亚型
RORγ RORα RORβ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research[1][2].

IC50 & Target[1]

RORγt

3.5 nM (Ki)

RORγt

17 nM (IC50)

体外研究
(In Vitro)

Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vimirogant 相关抗体:
体内研究
(In Vivo)

In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

552.65

Formula

C27H35F3N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vimirogant 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vimirogant1802706-04-2VTP-43742VTP43742VTP 43742RORRAR-related orphan receptorinflammatorycytokineIL-17ATh17cellsautoimmunedisorderspsoriasisarthritisPBMCInhibitorinhibitorinhibit

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目录号：
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