1. Metabolic Enzyme/Protease
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  3. Vimirogant

Vimirogant (Synonyms: VTP-43742)

目录号: HY-103637
产品使用指南

Vimirogant (VTP-43742) 是一种选择性、具有口服活性的的 RORγt 抑制剂 (Ki=3.5 nM; IC50=17 nM)。Vimirogant 与 RORα 和 RORβ 比,高出 >1000 倍的选择性。Vimirogant 抑制小鼠脾细胞的 Th17 分化和 IL-17A 分泌 (IC50=57 nM),而不会影响 Th1,Th2 或 Treg 细胞的分化。Vimirogant 可用于研究自身免疫性疾病研究。

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Vimirogant Chemical Structure

Vimirogant Chemical Structure

CAS No. : 1802706-04-2

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1 mg ¥7950
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  • 参考文献

生物活性

Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research[1][2].

IC50 & Target[1]

RORγt

3.5 nM (Ki)

RORγt

17 nM (IC50)

体外研究
(In Vitro)

Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

552.65

Formula

C27H35F3N4O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Vimirogant
目录号:
HY-103637
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